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| TissGeneSummary for SLC22A13 |
 Gene summary |
| Basic gene information | Gene symbol | SLC22A13 |
| Gene name | solute carrier family 22 (organic anion/urate transporter), member 13 | |
| Synonyms | OAT10|OCTL1|OCTL3|ORCTL-3|ORCTL3 | |
| Cytomap | UCSC genome browser: 3p21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004256.3, | |
| Description | organic cation transporter-like 3organic cationic transporter-like 3organic-cation transporter like 3solute carrier family 22 (organic anion transporter), member 13solute carrier family 22 member 13solute carrier family 22, member 13 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604047 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000172940 | ||
| HPRD : 06810 | ||
| Vega : OTTHUMG00000131086 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC22A13 | |
| BioGPS: 9390 | ||
| Pathway | NCI Pathway Interaction Database: SLC22A13 | |
| KEGG: SLC22A13 | ||
| REACTOME: SLC22A13 | ||
| Pathway Commons: SLC22A13 | ||
| Context | iHOP: SLC22A13 | |
| ligand binding site mutation search in PubMed: SLC22A13 | ||
| UCL Cancer Institute: SLC22A13 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
| Reference showing the relevant tissue of SLC22A13 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0015747 | urate transport | 10072596 | GO:2001142 | nicotinate transport | 18411268 | GO:0015747 | urate transport | 10072596 | GO:2001142 | nicotinate transport | 18411268 |
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| TissGeneExp for SLC22A13 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -1.51950979 | 3.17854621 | -4.698056 | 4.88E-10 | 3.33E-09 |
| KIRP | 1.44221921 | 5.392166085 | -3.949946875 | 4.56E-08 | 3.00E-07 |
| KIRC | 1.250416432 | 4.134126154 | -2.883709722 | 5.56E-10 | 1.85E-09 |
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| TissGene-miRNA for SLC22A13 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SLC22A13 |
| TissGeneSNV for SLC22A13 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R133W | BLCA | 1 |
| p.P523S | SKCM | 1 |
| p.L172F | UCEC | 1 |
| p.R161Q | UCEC | 1 |
| p.H58Y | LUSC | 1 |
| p.A2V | THYM | 1 |
| p.R461Q | UCEC | 1 |
| p.R331W | STAD | 1 |
| p.S122F | SKCM | 1 |
| p.G370E | UCEC | 1 |
| p.L31M | KIRC | 1 |
| p.T434A | UCEC | 1 |
| p.Q205E | CESC | 1 |
| p.G12C | LGG | 1 |
| p.G425R | UCEC | 1 |
| p.Q354X | SKCM | 1 |
| p.C404F | LGG | 1 |
| p.R377S | KIRP | 1 |
| p.P304S | SKCM | 1 |
| p.L148V | CESC | 1 |
| p.Q254R | UCEC | 1 |
| p.R389H | PAAD | 1 |
| p.S460* | ESCA | 1 |
| p.D285Y | LUAD | 1 |
| p.R449_splice | UCEC | 1 |
| p.G542V | LUAD | 1 |
| p.G179S | STAD | 1 |
| p.C50F | THYM | 1 |
| p.P89L | LUSC | 1 |
| p.R16P | LUAD | 1 |
| p.E126K | BLCA | 1 |
| p.T223M | UCEC | 1 |
| p.V416E | LUAD | 1 |
| p.D130N | SKCM | 1 |
| p.Q354* | SKCM | 1 |
| p.R164H | LGG | 1 |
| p.R102H | THCA | 1 |
| p.L84F | SKCM | 1 |
| p.C50R | UCEC | 1 |
| p.E117K | CESC | 1 |
| p.P541L | UCEC | 1 |
| p.A144S | LUAD | 1 |
| p.P304L | KICH | 1 |
| p.L364V | BLCA | 1 |
| p.E215X | COAD | 1 |
| p.I447V | BLCA | 1 |
| p.S460X | ESCA | 1 |
| p.L360P | KIRP | 1 |
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| TissGeneCNV for SLC22A13 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SLC22A13 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SLC22A13 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for SLC22A13 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SLC22A13 |
| TissGeneDrug for SLC22A13 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SLC22A13 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0022665 | Kidney Neoplasm | 2 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
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