TissGeneSummary for NAPSA |
Gene summary |
Basic gene information | Gene symbol | NAPSA |
Gene name | napsin A aspartic peptidase | |
Synonyms | KAP|Kdap|NAP1|NAPA|SNAPA | |
Cytomap | UCSC genome browser: 19q13.33 | |
Type of gene | protein-coding | |
RefGenes | NM_004851.1, | |
Description | ASP4TA01/TA02asp 4aspartyl protease 4kidney-derived aspartic protease-like proteinnapsin-1napsin-Apronapsin A | |
Modification date | 20141207 | |
dbXrefs | MIM : 605631 | |
HGNC : HGNC | ||
Ensembl : ENSG00000131400 | ||
HPRD : 07064 | ||
Vega : OTTHUMG00000183035 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NAPSA | |
BioGPS: 9476 | ||
Pathway | NCI Pathway Interaction Database: NAPSA | |
KEGG: NAPSA | ||
REACTOME: NAPSA | ||
Pathway Commons: NAPSA | ||
Context | iHOP: NAPSA | |
ligand binding site mutation search in PubMed: NAPSA | ||
UCL Cancer Institute: NAPSA | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Lung | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSC | |
Reference showing the relevant tissue of NAPSA | The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling. Lindskog C, Fagerberg L, Hallström B, Edlund K, Hellwig B, Rahnenführer J, Kampf C, Uhlén M, Pontén F, Micke P. FASEB J. 2014 Dec;28(12):5184-96. doi: 10.1096/fj.14-254862. Epub 2014 Aug 28 (pmid:25169055) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0033619 | membrane protein proteolysis | 14766755 | GO:0043129 | surfactant homeostasis | 18216060 | GO:0033619 | membrane protein proteolysis | 14766755 | GO:0043129 | surfactant homeostasis | 18216060 |
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TissGeneExp for NAPSA |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 4.728707033 | 11.43212076 | -6.703413726 | 1.24E-16 | 9.47E-16 |
LUAD | 9.613700712 | 11.52184899 | -1.908148276 | 1.57E-06 | 5.14E-06 |
KICH | -1.802923633 | 5.656208367 | -7.459132 | 5.64E-27 | 1.78E-24 |
KIRC | 3.997962589 | 5.967102867 | -1.969140278 | 5.69E-08 | 1.62E-07 |
THCA | 2.751899689 | 0.121928502 | 2.629971186 | 1.51E-12 | 1.29E-11 |
KIRP | 5.357371617 | 6.528537242 | -1.171165625 | 0.0242 | 0.048142325 |
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TissGene-miRNA for NAPSA |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for NAPSA |
TissGeneSNV for NAPSA |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R121Q | UCEC | 3 |
p.R348Q | LGG | 1 |
p.L206V | STAD | 1 |
p.V205I | LGG | 1 |
p.A179T | UCEC | 1 |
p.P105S | SKCM | 1 |
p.F219S | LIHC | 1 |
p.S327C | BLCA | 1 |
p.I82T | READ | 1 |
p.R264H | UCEC | 1 |
p.R145Q | STAD | 1 |
p.R404C | PAAD | 1 |
p.A414V | HNSC | 1 |
p.R352H | PAAD | 1 |
p.A406V | LGG | 1 |
p.E294K | HNSC | 1 |
p.I40T | COAD | 1 |
p.V343I | PRAD | 1 |
p.L273I | UCEC | 1 |
p.G168R | STAD | 1 |
p.R352H | BLCA | 1 |
p.R121Q | CESC | 1 |
p.R348L | KIRP | 1 |
p.S327Y | THYM | 1 |
p.V343I | KIRC | 1 |
p.H32N | COAD | 1 |
p.R200Q | PRAD | 1 |
p.N72K | ESCA | 1 |
p.R400H | HNSC | 1 |
p.P9S | LUAD | 1 |
p.M390R | LIHC | 1 |
p.P50T | STAD | 1 |
p.Y381N | HNSC | 1 |
p.A399P | HNSC | 1 |
p.V376I | SKCM | 1 |
p.G332E | SKCM | 1 |
p.P225H | ESCA | 1 |
p.P364H | STAD | 1 |
p.G62E | SKCM | 1 |
p.S287F | SKCM | 1 |
p.F111Y | SARC | 1 |
p.D204N | LUSC | 1 |
p.T284A | STAD | 1 |
p.P365T | THYM | 1 |
p.I260M | LUAD | 1 |
p.A394T | ESCA | 1 |
p.D96G | READ | 1 |
p.V343I | LAML | 1 |
p.G397S | THYM | 1 |
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TissGeneCNV for NAPSA |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NAPSA |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for NAPSA |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NAPSA |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NAPSA |
TissGeneDrug for NAPSA |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NAPSA |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0343386 | Clostridium difficile infection | 10 | BeFree |
umls:C0001418 | Adenocarcinoma | 9 | BeFree,LHGDN |
umls:C0152013 | Adenocarcinoma of lung (disorder) | 4 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 3 | BeFree |
umls:C0011991 | Diarrhea | 2 | BeFree |
umls:C0017636 | Glioblastoma | 2 | BeFree |
umls:C0032002 | Pituitary Diseases | 2 | BeFree |
umls:C0206681 | Adenocarcinoma, Clear Cell | 2 | BeFree |
umls:C0684249 | Carcinoma of lung | 2 | BeFree |
umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
umls:C0004114 | Astrocytoma | 1 | BeFree |
umls:C0013336 | Dwarfism | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0033860 | Psoriasis | 1 | BeFree |
umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
umls:C0243026 | Sepsis | 1 | BeFree |
umls:C0281361 | Adenocarcinoma of pancreas | 1 | BeFree |
umls:C0578159 | Antibiotic-associated diarrhea | 1 | BeFree |
umls:C0600427 | Cocaine Dependence | 1 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
umls:C0919267 | ovarian neoplasm | 1 | BeFree |