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| TissGeneSummary for TBPL1 |
 Gene summary |
| Basic gene information | Gene symbol | TBPL1 |
| Gene name | TBP-like 1 | |
| Synonyms | MGC:8389|MGC:9620|STUD|TLF|TLP|TRF2 | |
| Cytomap | UCSC genome browser: 6q22.1-q22.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001253676.1, NM_004865.3, | |
| Description | 21-kDA TBP-like proteinTATA box-binding protein-like protein 1TATA box-binding protein-related factor 2TBP-related factor 2TBP-related proteinsecond TBP of unique DNA protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605521 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000028839 | ||
| HPRD : 09272 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TBPL1 | |
| BioGPS: 9519 | ||
| Pathway | NCI Pathway Interaction Database: TBPL1 | |
| KEGG: TBPL1 | ||
| REACTOME: TBPL1 | ||
| Pathway Commons: TBPL1 | ||
| Context | iHOP: TBPL1 | |
| ligand binding site mutation search in PubMed: TBPL1 | ||
| UCL Cancer Institute: TBPL1 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLTGCT | |
| Reference showing the relevant tissue of TBPL1 | Expression of a testis-specific form of TBP-related factor 2 (TRF2) mRNA during mouse spermatogenesis. J Reprod Dev. 2003 Feb;49(1):107-11. (pmid:14967955) go to article | |
| Description by TissGene annotations | Have significant anti-correlated miRNA TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for TBPL1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for TBPL1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-148a-3p | MIMAT0000243 | 0.024 | -0.26 | 78 |
| ACC | hsa-miR-148a-3p | MIMAT0000243 | 0.024 | -0.26 | 78 |
| UCS | hsa-miR-301b-3p | MIMAT0004958 | 0.043 | -0.27 | 56 |
| UCS | hsa-miR-454-3p | MIMAT0003885 | 0.041 | -0.28 | 56 |
| ACC | hsa-miR-15a-5p | MIMAT0000068 | 0.0082 | -0.3 | 78 |
| ACC | hsa-miR-15a-5p | MIMAT0000068 | 0.0082 | -0.3 | 78 |
| UCS | hsa-miR-194-5p | MIMAT0000460 | 0.025 | -0.3 | 56 |
| UCS | hsa-miR-30d-5p | MIMAT0000245 | 0.02 | -0.31 | 56 |
| UCS | hsa-miR-181c-5p | MIMAT0000258 | 0.02 | -0.31 | 56 |
| UCS | hsa-miR-181d-5p | MIMAT0002821 | 0.019 | -0.31 | 56 |
| UCS | hsa-miR-148b-3p | MIMAT0000759 | 0.022 | -0.31 | 56 |
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| TissGeneMut for TBPL1 |
| TissGeneSNV for TBPL1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S5T | SARC | 1 |
| p.A32S | SARC | 1 |
| p.Y130N | COAD | 1 |
| p.R146T | CESC | 1 |
| p.S181G | HNSC | 1 |
| p.F152L | UCEC | 1 |
| p.D99E | UCEC | 1 |
| p.R29M | UCEC | 1 |
| p.Q150X | LIHC | 1 |
| p.R141Q | STAD | 1 |
| p.A77V | SKCM | 1 |
| p.Q173H | UCEC | 1 |
| p.I67V | UCEC | 1 |
| p.P118T | STAD | 1 |
| p.I115V | ESCA | 1 |
| p.E75K | BLCA | 1 |
| p.E184D | READ | 1 |
| p.R42C | LGG | 1 |
| p.Q150* | LIHC | 1 |
| p.Y130S | UCEC | 1 |
| p.D99H | CESC | 1 |
| p.F120L | UCEC | 1 |
| p.G35E | LUAD | 1 |
| p.F100C | COAD | 1 |
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| TissGeneCNV for TBPL1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TBPL1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF919684 | TBPL1-EDEM3 | chr6:134301303 | chr1:184662691 |
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| TissGeneNet for TBPL1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| TBPL1, TBP, ELAVL1, TAF6, RPL10, TERF1, HNF1A, GTF2B, TAF5, PRNP, HSPA9, TAF1L, PMVK, RAB35, IRAK4, PTCD3, GTF2A2, GTF2A1, TAF4, PLIN3, ABCF3 (tumor) | TBPL1, TBP, ELAVL1, S100A9, TERF2, TAF6, RPL10, HNF1A, GTF2B, TAF5, PRNP, HSPA9, TAF1L, PMVK, TAF1, IRAK4, NF1, PTCD3, GTF2A2, PLIN3, NDUFA6 (normal) |
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| COAD (tumor) | COAD (normal) |
| TBPL1, TBP, ELAVL1, S100A9, TERF2, TAF6, RPL10, GTF2B, TAF5, TAF1L, TAF1, HOXA13, RAB35, IRAK4, NF1, PTCD3, GTF2A2, TAF4, TBPL2, ABCF3, NDUFA6 (tumor) | TBPL1, TBP, ELAVL1, TERF2, TAF6, RPL10, TERF1, GTF2B, TAF1L, PMVK, TAF1, HOXA13, RAB35, IRAK4, NF1, PTCD3, GTF2A2, GTF2A1, TBPL2, ABCF3, NDUFA6 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| TBPL1, TBP, ELAVL1, S100A9, TERF2, TAF6, HNF1A, GTF2B, TAF5, PRNP, HSPA9, PMVK, HOXA13, RAB35, IRAK4, NF1, PTCD3, GTF2A2, TAF4, PLIN3, ABCF3 (tumor) | TBPL1, TBP, ELAVL1, S100A9, TERF1, HNF1A, GTF2B, TAF5, PRNP, TAF1L, PMVK, TAF1, HOXA13, RAB35, PTCD3, GTF2A2, GTF2A1, PLIN3, TBPL2, ABCF3, NDUFA6 (normal) |
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| KICH (tumor) | KICH (normal) |
| TBPL1, TBP, ELAVL1, S100A9, TERF2, TAF6, RPL10, HNF1A, GTF2B, TAF5, TAF1L, TAF1, HOXA13, IRAK4, NF1, GTF2A2, GTF2A1, TAF4, PLIN3, ABCF3, NDUFA6 (tumor) | TBPL1, TBP, ELAVL1, S100A9, TERF2, HNF1A, TAF5, PRNP, HSPA9, PMVK, HOXA13, RAB35, IRAK4, NF1, PTCD3, GTF2A2, GTF2A1, TAF4, PLIN3, ABCF3, NDUFA6 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| TBPL1, TBP, S100A9, RPL10, TERF1, HNF1A, GTF2B, TAF5, PRNP, HSPA9, TAF1L, PMVK, TAF1, RAB35, IRAK4, NF1, PTCD3, GTF2A2, TAF4, PLIN3, ABCF3 (tumor) | TBPL1, TBP, ELAVL1, S100A9, TAF6, RPL10, TERF1, HNF1A, GTF2B, TAF5, PRNP, HSPA9, TAF1L, PMVK, TAF1, IRAK4, NF1, PTCD3, GTF2A2, TAF4, ABCF3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| TBPL1, TBP, TERF2, TAF6, RPL10, TERF1, HNF1A, GTF2B, TAF5, PRNP, HSPA9, TAF1L, TAF1, HOXA13, IRAK4, NF1, GTF2A2, GTF2A1, TAF4, PLIN3, NDUFA6 (tumor) | TBPL1, TBP, ELAVL1, S100A9, TAF6, RPL10, TERF1, HNF1A, GTF2B, TAF5, TAF1L, PMVK, HOXA13, IRAK4, NF1, PTCD3, GTF2A2, PLIN3, TBPL2, ABCF3, NDUFA6 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| TBPL1, TBP, S100A9, TERF2, TAF6, RPL10, TERF1, HNF1A, GTF2B, TAF5, PRNP, TAF1L, TAF1, RAB35, IRAK4, GTF2A2, GTF2A1, TAF4, PLIN3, ABCF3, NDUFA6 (tumor) | TBPL1, TBP, ELAVL1, S100A9, TERF2, TAF6, TERF1, HNF1A, GTF2B, TAF5, PRNP, HSPA9, PMVK, RAB35, IRAK4, NF1, PTCD3, GTF2A2, PLIN3, ABCF3, NDUFA6 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| TBPL1, TBP, ELAVL1, TERF2, TAF6, RPL10, TERF1, GTF2B, PRNP, HSPA9, TAF1L, PMVK, TAF1, HOXA13, IRAK4, NF1, PTCD3, GTF2A2, GTF2A1, TAF4, NDUFA6 (tumor) | TBPL1, TBP, S100A9, TERF2, RPL10, TERF1, GTF2B, TAF5, PRNP, TAF1L, PMVK, TAF1, HOXA13, RAB35, IRAK4, NF1, PTCD3, GTF2A2, GTF2A1, TAF4, NDUFA6 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| TBPL1, TBP, ELAVL1, S100A9, TERF2, TAF6, RPL10, TERF1, HNF1A, GTF2B, TAF5, PRNP, TAF1, RAB35, IRAK4, NF1, PTCD3, GTF2A2, TAF4, ABCF3, NDUFA6 (tumor) | TBPL1, TBP, ELAVL1, TERF2, TAF6, RPL10, TERF1, HNF1A, GTF2B, TAF5, PRNP, TAF1L, PMVK, TAF1, IRAK4, PTCD3, GTF2A2, TAF4, PLIN3, ABCF3, NDUFA6 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| TBPL1, TBP, ELAVL1, S100A9, TERF2, TAF6, RPL10, TERF1, GTF2B, TAF5, HSPA9, TAF1L, PMVK, TAF1, IRAK4, NF1, GTF2A2, GTF2A1, TBPL2, ABCF3, NDUFA6 (tumor) | TBPL1, TBP, ELAVL1, TERF2, TAF6, HNF1A, GTF2B, TAF5, PRNP, TAF1L, PMVK, TAF1, RAB35, NF1, PTCD3, GTF2A2, GTF2A1, TAF4, PLIN3, ABCF3, NDUFA6 (normal) |
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| STAD (tumor) | STAD (normal) |
| TBPL1, TBP, ELAVL1, TERF2, TAF6, RPL10, TERF1, HNF1A, GTF2B, PRNP, HSPA9, TAF1L, PMVK, TAF1, IRAK4, NF1, GTF2A2, GTF2A1, TAF4, ABCF3, NDUFA6 (tumor) | TBPL1, TBP, ELAVL1, TAF6, RPL10, TERF1, HNF1A, GTF2B, TAF5, PRNP, PMVK, HOXA13, RAB35, IRAK4, PTCD3, GTF2A2, GTF2A1, TAF4, PLIN3, TBPL2, ABCF3 (normal) |
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| THCA (tumor) | THCA (normal) |
| TBPL1, TBP, ELAVL1, S100A9, TAF6, RPL10, TERF1, GTF2B, TAF5, PRNP, HSPA9, TAF1L, TAF1, HOXA13, IRAK4, NF1, PTCD3, GTF2A2, GTF2A1, PLIN3, ABCF3 (tumor) | TBPL1, TBP, ELAVL1, S100A9, TERF2, TAF6, TERF1, HNF1A, GTF2B, TAF5, HSPA9, TAF1L, TAF1, RAB35, IRAK4, NF1, PTCD3, GTF2A2, TAF4, PLIN3, NDUFA6 (normal) |
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| TissGeneProg for TBPL1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for TBPL1 |
| TissGeneDrug for TBPL1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for TBPL1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0596263 | Carcinogenesis | 8 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 6 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 6 | BeFree |
| umls:C0699790 | Colon Carcinoma | 5 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 4 | BeFree |
| umls:C0023264 | Leigh Disease | 3 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0007114 | Malignant neoplasm of skin | 2 | BeFree |
| umls:C0007124 | Noninfiltrating Intraductal Carcinoma | 2 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 2 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
| umls:C0017668 | Focal glomerulosclerosis | 2 | BeFree |
| umls:C0019693 | HIV Infections | 2 | BeFree |
| umls:C0022658 | Kidney Diseases | 2 | BeFree |
| umls:C0022680 | Polycystic Kidney Diseases | 2 | BeFree |
| umls:C0023492 | Leukemia, T-Cell | 2 | BeFree |
| umls:C0023493 | Adult T-Cell Lymphoma/Leukemia | 2 | BeFree |
| umls:C0025202 | melanoma | 2 | BeFree |
| umls:C0085413 | Polycystic Kidney, Autosomal Dominant | 2 | BeFree |
| umls:C0085669 | Acute leukemia | 2 | BeFree |
| umls:C0162670 | Mitochondrial Myopathies | 2 | BeFree |
| umls:C0238286 | Mucolipidosis Type IV | 2 | BeFree |
| umls:C0333307 | Superficial ulcer | 2 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
| umls:C0600139 | Prostate carcinoma | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C1334274 | Invasive Carcinoma | 2 | BeFree |
| umls:C1527249 | Colorectal Cancer | 2 | BeFree |
| umls:C1720983 | Channelopathies | 2 | BeFree |
| umls:C2239176 | Liver carcinoma | 2 | BeFree |
| umls:C0004096 | Asthma | 1 | BeFree |
| umls:C0004134 | Ataxia | 1 | BeFree |
| umls:C0004277 | Tooth Attrition | 1 | BeFree |
| umls:C0004509 | Azoospermia | 1 | GAD |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0009324 | Ulcerative Colitis | 1 | BeFree |
| umls:C0010200 | Coughing | 1 | BeFree |
| umls:C0010346 | Crohn Disease | 1 | BeFree |
| umls:C0015625 | Fanconi Anemia | 1 | BeFree |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0018801 | Heart failure | 1 | BeFree |
| umls:C0018802 | Congestive heart failure | 1 | BeFree |
| umls:C0021364 | Male infertility | 1 | GAD |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0023895 | Liver diseases | 1 | BeFree |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0026470 | Monoclonal Gammopathy of Undetermined Significance | 1 | BeFree |
| umls:C0026764 | Multiple Myeloma | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0027819 | Neuroblastoma | 1 | BeFree |
| umls:C0028043 | Nicotine Dependence | 1 | BeFree |
| umls:C0028960 | Oligospermia | 1 | GAD |
| umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
| umls:C0035304 | Retinal Degeneration | 1 | BeFree |
| umls:C0037286 | Skin Neoplasms | 1 | BeFree |
| umls:C0087012 | Ataxia, Spinocerebellar | 1 | BeFree |
| umls:C0149931 | Migraine Disorders | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0205711 | Pelizaeus-Merzbacher Disease | 1 | BeFree |
| umls:C0220633 | Uveal melanoma | 1 | BeFree |
| umls:C0231341 | Premature aging syndrome | 1 | BeFree |
| umls:C0264716 | Chronic heart failure | 1 | BeFree |
| umls:C0268731 | Renal glomerular disease | 1 | BeFree |
| umls:C0282193 | Iron Overload | 1 | BeFree |
| umls:C0282488 | Interstitial Cystitis | 1 | BeFree |
| umls:C0338480 | Common Migraine | 1 | BeFree |
| umls:C0398791 | Nijmegen Breakage Syndrome | 1 | BeFree |
| umls:C0600040 | Chronic interstitial cystitis | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C0700095 | Central neuroblastoma | 1 | BeFree |
| umls:C0728936 | Disorder of circulatory system | 1 | BeFree |
| umls:C0751038 | Cockayne Syndrome, Type II | 1 | BeFree |
| umls:C0877373 | Advanced cancer | 1 | BeFree |
| umls:C0940937 | precancerous lesions | 1 | BeFree |
| umls:C1285162 | Degenerative disorder | 1 | BeFree |
| umls:C1292769 | Precursor B-cell lymphoblastic leukemia | 1 | BeFree |
| umls:C1511789 | Desmoplastic | 1 | BeFree |
| umls:C1512409 | Hepatocarcinogenesis | 1 | BeFree |
| umls:C1709246 | Non-Neoplastic Disorder | 1 | BeFree |
| umls:C1846058 | Lubs X-linked mental retardation syndrome | 1 | BeFree |
| umls:C2745900 | Promyelocytic leukemia | 1 | BeFree |
| umls:C3469521 | FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 1 | BeFree |
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