TissGeneSummary for IGDCC3 |
Gene summary |
Basic gene information | Gene symbol | IGDCC3 |
Gene name | immunoglobulin superfamily, DCC subclass, member 3 | |
Synonyms | HsT18880|PUNC | |
Cytomap | UCSC genome browser: 15q22.3-q23 | |
Type of gene | protein-coding | |
RefGenes | NM_004884.3, | |
Description | immunoglobulin superfamily DCC subclass member 3putative neuronal cell adhesion molecule | |
Modification date | 20141207 | |
dbXrefs | MIM : 604184 | |
HGNC : HGNC | ||
Ensembl : ENSG00000174498 | ||
HPRD : 09169 | ||
Vega : OTTHUMG00000133137 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IGDCC3 | |
BioGPS: 9543 | ||
Pathway | NCI Pathway Interaction Database: IGDCC3 | |
KEGG: IGDCC3 | ||
REACTOME: IGDCC3 | ||
Pathway Commons: IGDCC3 | ||
Context | iHOP: IGDCC3 | |
ligand binding site mutation search in PubMed: IGDCC3 | ||
UCL Cancer Institute: IGDCC3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUVM | |
Reference showing the relevant tissue of IGDCC3 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for IGDCC3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -2.794738139 | -0.485403417 | -2.309334722 | 4.23E-23 | 4.29E-22 |
KIRP | -3.365106542 | 0.049762208 | -3.41486875 | 2.28E-18 | 1.09E-16 |
KICH | -1.983090917 | -0.974538917 | -1.008552 | 0.00639 | 0.011986009 |
LIHC | -2.657530917 | -3.907988917 | 1.250458 | 0.000405 | 0.001205771 |
BRCA | -0.734370741 | 0.32220382 | -1.056574561 | 0.000542 | 0.00109665 |
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TissGene-miRNA for IGDCC3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-4262 | MIMAT0016894 | 0.025 | -0.26 | 78 |
ACC | hsa-miR-4262 | MIMAT0016894 | 0.025 | -0.26 | 78 |
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TissGeneMut for IGDCC3 |
TissGeneSNV for IGDCC3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V751L | PCPG | 4 |
p.R805W | SKCM | 2 |
p.P786T | LUAD | 1 |
p.R200G | BLCA | 1 |
p.R608H | LIHC | 1 |
p.Q146H | ESCA | 1 |
p.E184Q | BRCA | 1 |
p.T319K | ESCA | 1 |
p.G391S | UCEC | 1 |
p.S750Y | SKCM | 1 |
p.E41K | READ | 1 |
p.V589M | UCEC | 1 |
p.A493V | SKCM | 1 |
p.A774V | SKCM | 1 |
p.E709K | CESC | 1 |
p.V673A | LUAD | 1 |
p.E453A | UCEC | 1 |
p.E813* | LUAD | 1 |
p.R414M | ESCA | 1 |
p.S578F | BLCA | 1 |
p.P730L | ESCA | 1 |
p.Q599K | LUAD | 1 |
p.R277C | SKCM | 1 |
p.V751L | BRCA | 1 |
p.V304I | LUAD | 1 |
p.E41* | KIRC | 1 |
p.V251M | UCEC | 1 |
p.A500T | LUSC | 1 |
p.R132C | SKCM | 1 |
p.R664M | LUAD | 1 |
p.A620S | PRAD | 1 |
p.H100P | HNSC | 1 |
p.R200Q | UCEC | 1 |
p.D180H | CESC | 1 |
p.E630K | HNSC | 1 |
p.H38Q | LUAD | 1 |
p.T575N | THYM | 1 |
p.E617K | LUAD | 1 |
p.E766K | BRCA | 1 |
p.R176K | SKCM | 1 |
p.V642I | THYM | 1 |
p.E813K | CESC | 1 |
p.R431W | STAD | 1 |
p.N381S | LIHC | 1 |
p.G778S | UCEC | 1 |
p.P683S | SKCM | 1 |
p.A211V | PRAD | 1 |
p.G644V | OV | 1 |
p.P426H | PAAD | 1 |
p.P426T | LUAD | 1 |
p.Q583K | THYM | 1 |
p.G425R | SKCM | 1 |
p.E469G | OV | 1 |
p.A136E | LUAD | 1 |
p.M348L | OV | 1 |
p.P586S | SKCM | 1 |
p.V592A | UCEC | 1 |
p.L90W | BRCA | 1 |
p.E403* | LUSC | 1 |
p.E551K | LUAD | 1 |
p.R200* | BRCA | 1 |
p.R711C | LGG | 1 |
p.A727S | STAD | 1 |
p.V435M | LIHC | 1 |
p.P683S | STAD | 1 |
p.R157C | SKCM | 1 |
p.F721L | KIRC | 1 |
p.R702W | LIHC | 1 |
p.A767V | COAD | 1 |
p.R711C | UCEC | 1 |
p.A211V | SKCM | 1 |
p.R323L | COAD | 1 |
p.A548V | SKCM | 1 |
p.R431W | PRAD | 1 |
p.E771V | GBM | 1 |
p.V54I | ESCA | 1 |
p.L96V | SKCM | 1 |
p.G233R | SKCM | 1 |
p.N175I | UCEC | 1 |
p.G758S | BLCA | 1 |
p.A588V | BRCA | 1 |
p.M97I | SKCM | 1 |
p.R72Q | PRAD | 1 |
p.V149M | UCEC | 1 |
p.R618K | SKCM | 1 |
p.V440A | STAD | 1 |
p.D182V | KIRC | 1 |
p.A742T | LIHC | 1 |
p.D708Y | SARC | 1 |
p.T314I | LUSC | 1 |
p.R707Q | SARC | 1 |
p.A215T | STAD | 1 |
p.A131D | LUAD | 1 |
p.P55L | GBM | 1 |
p.T319M | LGG | 1 |
p.A810T | UCEC | 1 |
p.E84* | BLCA | 1 |
p.D203G | STAD | 1 |
p.Q538H | PRAD | 1 |
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TissGeneCNV for IGDCC3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for IGDCC3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE093173 | IGDCC3-TNRC18 | chr15:65622103 | chr7:5432773 | |
Chimerdb3.0 | ChiTaRs | NA | R23707 | IGDCC3-KIF3B | chr15:65621004 | chr20:30922597 | |
Chimerdb3.0 | FusionScan | LGG | TCGA-DB-5277-01A | IGDCC3-GLDN | In-Frame | chr15:65667434 | chr15:51675981 |
TCGAfusionPortal | PRADA | LGG | TCGA-DB-5277-01A | IGDCC3-GLDN | In-frame | Chr15:65667435 | Chr15:51675982 |
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TissGeneNet for IGDCC3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for IGDCC3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for IGDCC3 |
TissGeneDrug for IGDCC3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for IGDCC3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |