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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for KLK4
check button Gene summary
Basic gene informationGene symbolKLK4
Gene namekallikrein-related peptidase 4
SynonymsAI2A1|ARM1|EMSP|EMSP1|KLK-L1|PRSS17|PSTS|kallikrein
CytomapUCSC genome browser: 19q13.41
Type of geneprotein-coding
RefGenesNM_001302961.1,
NM_004917.4,NR_126566.1,
Descriptionandrogen-regulated message 1enamel matrix serine protease 1enamel matrix serine proteinase 1kallikrein-4kallikrein-like protein 1prostaseserine protease 17
Modification date20141207
dbXrefs MIM : 603767
HGNC : HGNC
Ensembl : ENSG00000167749
HPRD : 04793
Vega : OTTHUMG00000182964
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KLK4
BioGPS: 9622
PathwayNCI Pathway Interaction Database: KLK4
KEGG: KLK4
REACTOME: KLK4
Pathway Commons: KLK4
ContextiHOP: KLK4
ligand binding site mutation search in PubMed: KLK4
UCL Cancer Institute: KLK4
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Prostate
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PRAD
Reference showing the relevant tissue of KLK4Expression of human kallikrein 1-related peptidase 4 (KLK4) and MET phosphorylation in prostate cancer tissue: immunohistochemical analysis. Mukai S, Yorita K, Yamasaki K, Nagai T, Kamibeppu T, Sugie S, Kida K, Onizuka C, Tsukino H, Kamimura T, Kamoto T, Kataoka H. Hum Cell. 2015 Jul;28(3):133-42. doi: 10.1007/s13577-015-0114-6. Epub 2015 Apr 11. (pmid:25862631)
go to article
Description by TissGene annotationsProtective TissGene in RFS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for KLK4

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC-2.229793591-3.5697308461.3399372553.14E-078.35E-07
THCA-0.7986653422.171260081-2.9699254246.97E-136.46E-12
BRCA0.606485357-1.8499585032.456443862.42E-201.77E-19
KICH5.706447742-2.3980762588.1045247.55E-141.12E-12
LIHC-3.200580258-4.3739922581.1734120.002020.005144977
PRAD9.608857058.0950878191.5137692319.32E-050.000393336


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TissGene-miRNA for KLK4

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for KLK4
TissGeneSNV for KLK4

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.T244SLUAD1
p.G34DPRAD1
p.G159SSTAD1
p.T131NUCEC1
p.G219SSKCM1
p.A157VUCEC1
p.T143ISKCM1
p.A144ELUAD1
p.E35XSKCM1
p.G159SESCA1
p.P39LLUAD1
p.L117FSKCM1
p.A88VSKCM1
p.A144TPAAD1
p.E51GSKCM1
p.G215RSKCM1
p.D116NUCEC1
p.V97MUCEC1
p.V164MCOAD1
p.S102FSKCM1
p.G21*UCEC1
p.A70TUCEC1
p.A226SBRCA1
p.G159SLGG1
p.V150ICOAD1
p.G215RUCEC1
p.P210ASTAD1
p.L83PSTAD1
p.V233MUCEC1
p.S22ACOAD1
p.S139LUCEC1
p.C192*HNSC1
p.V150IESCA1
p.Q95HLUAD1
p.C37YLGG1
p.L117ILGG1
p.Q230HESCA1
p.S139LSTAD1
p.H40QPRAD1
p.E53KSKCM1
p.S139LREAD1


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TissGeneCNV for KLK4

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for KLK4

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABI020974KIF1C-KLK4chr17:4905402chr19:51410114
Chimerdb3.0FusionScanPRADTCGA-G9-6499-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-J9-A52E-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-V1-A9Z8-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-J9-A52D-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-EJ-5515-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-ZG-A8QZ-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-XK-AAJ3-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-V1-A9Z7-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-G9-6377-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-G9-A9S4-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-CH-5769-11AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-TP-A8TV-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-G9-7521-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-KK-A8IF-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-EJ-7325-01BKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-HC-A6AL-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-EJ-A7NH-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-YL-A8SQ-01BKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-G9-6339-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-HC-7747-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-V1-A8ML-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-KC-A7FD-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-G9-7519-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-Y6-A8TL-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-KK-A7AZ-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-KK-A7AP-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-HC-7819-11AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-YL-A8HO-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-M7-A724-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-HC-7738-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-XK-AAK1-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-J4-A67N-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-V1-A8MJ-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-G9-6369-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-J4-A67L-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-EJ-7123-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-J4-8200-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-KC-A7FA-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-CH-5745-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-EJ-A65B-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-YL-A9WX-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-2A-AAYF-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-HC-7213-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-EJ-5532-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-HC-A76X-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-G9-7525-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-X4-A8KQ-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-EJ-5494-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-KK-A8I5-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-XQ-A8TA-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-KK-A6E8-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-XJ-A9DK-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-CH-5772-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-CH-5748-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-CH-5746-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-V1-A9OY-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-HC-7080-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-EJ-A65G-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-EJ-5527-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-MG-AAMC-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-V1-A8MM-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-V1-A9OH-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-YJ-A8SW-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-G9-6336-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-EJ-5519-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-EJ-5517-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-HI-7171-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-EJ-A7NF-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-VP-A875-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-EJ-7328-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-HC-7820-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-G9-6371-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-HC-A8CY-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-ZG-A8QW-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-J4-A67M-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-KK-A6E0-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-EJ-7792-11AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-KK-A7B4-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-HC-8258-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-G9-6366-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-G9-6385-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-EJ-7781-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-G9-6338-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-G9-6333-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-KK-A7B2-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-CH-5762-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-KK-A59V-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-KK-A5A1-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-YL-A8S8-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-HC-8260-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-EJ-5503-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-KK-A6E7-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-HI-7170-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-CH-5794-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-G9-6351-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-EJ-7317-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-H9-7775-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-HC-7210-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-FC-A8O0-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
Chimerdb3.0FusionScanPRADTCGA-XK-AAJA-01AKLK4-PRSS36Out-of-Framechr19:51411834chr16:31155158
TCGAfusionPortalPRADABRCATCGA-AC-A5XU-01AKAT6A-KLK4Out-of-frameChr8:41798360Chr19:51412085


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TissGeneNet for KLK4

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
KLK4, SHBG, SERPINA3 (tumor)KLK4, SHBG, SERPINA3 (normal)
bullet pointbullet point
COAD (tumor)COAD (normal)
KLK4, SHBG, SERPINA3 (tumor)KLK4, SHBG, SERPINA3 (normal)
bullet pointbullet point
HNSC (tumor)HNSC (normal)
KLK4, SHBG, SERPINA3 (tumor)KLK4, SHBG, SERPINA3 (normal)
bullet pointbullet point
KICH (tumor)KICH (normal)
KLK4, SHBG, SERPINA3 (tumor)KLK4, SHBG, SERPINA3 (normal)
bullet pointbullet point
KIRC (tumor)KIRC (normal)
KLK4, SHBG, SERPINA3 (tumor)KLK4, SHBG, SERPINA3 (normal)
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KIRP (tumor)KIRP (normal)
KLK4, SHBG, SERPINA3 (tumor)KLK4, SHBG, SERPINA3 (normal)
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LIHC (tumor)LIHC (normal)
KLK4, SHBG, SERPINA3 (tumor)KLK4, SHBG, SERPINA3 (normal)
bullet pointbullet point
LUAD (tumor)LUAD (normal)
KLK4, SHBG, SERPINA3 (tumor)KLK4, SHBG, SERPINA3 (normal)
bullet pointbullet point
LUSC (tumor)LUSC (normal)
KLK4, SHBG, SERPINA3 (tumor)KLK4, SHBG, SERPINA3 (normal)
bullet pointbullet point
PRAD (tumor)PRAD (normal)
KLK4, SHBG, SERPINA3 (tumor)KLK4, SHBG, SERPINA3 (normal)
bullet pointbullet point
STAD (tumor)STAD (normal)
KLK4, SHBG, SERPINA3 (tumor)KLK4, SHBG, SERPINA3 (normal)
bullet pointbullet point
THCA (tumor)THCA (normal)
KLK4, SHBG, SERPINA3 (tumor)KLK4, SHBG, SERPINA3 (normal)
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TissGeneProg for KLK4

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for KLK4
TissGeneDrug for KLK4

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for KLK4

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0376358Malignant neoplasm of prostate24BeFree,GAD
umls:C0600139Prostate carcinoma22BeFree
umls:C0029925Ovarian Carcinoma15BeFree
umls:C1140680Malignant neoplasm of ovary14BeFree
umls:C0020538Hypertensive disease12BeFree
umls:C0006142Malignant neoplasm of breast11BeFree,GAD
umls:C0033578Prostatic Neoplasms11BeFree,LHGDN
umls:C0678222Breast Carcinoma10BeFree
umls:C0002452Amelogenesis Imperfecta8BeFree,LHGDN
umls:C0022658Kidney Diseases5BeFree
umls:C0022116Ischemia3BeFree
umls:C0027627Neoplasm Metastasis3BeFree,LHGDN
umls:C0038454Cerebrovascular accident3BeFree
umls:C0476089Endometrial Carcinoma3BeFree
umls:C0677886Epithelial ovarian cancer3BeFree
umls:C1458155Mammary Neoplasms3BeFree,LHGDN
umls:C0007102Malignant tumor of colon2BeFree
umls:C0007103Malignant neoplasm of endometrium2BeFree
umls:C0007766Intracranial Aneurysm2BeFree
umls:C0007785Cerebral Infarction2BeFree
umls:C0022661Kidney Failure, Chronic2BeFree
umls:C0024141Lupus Erythematosus, Systemic2BeFree
umls:C0024143Lupus Nephritis2BeFree
umls:C0027051Myocardial Infarction2BeFree
umls:C0596263Carcinogenesis2BeFree
umls:C1883486Uterine Corpus Cancer2BeFree
umls:C0001418Adenocarcinoma1BeFree
umls:C0001430Adenoma1BeFree
umls:C0007134Renal Cell Carcinoma1BeFree
umls:C0009402Colorectal Carcinoma1BeFree
umls:C0010054Coronary Arteriosclerosis1BeFree
umls:C0011269Dementia, Vascular1BeFree
umls:C0011991Diarrhea1BeFree
umls:C0018206granulosa cell tumor1BeFree
umls:C0019693HIV Infections1BeFree
umls:C0023055Laryngeal neoplasm1BeFree
umls:C0023530Leukopenia1BeFree
umls:C0024131Lupus Vulgaris1BeFree
umls:C0024138Lupus Erythematosus, Discoid1BeFree
umls:C0027697Nephritis1BeFree
umls:C0027947Neutropenia1BeFree
umls:C0032002Pituitary Diseases1BeFree
umls:C0041956Ureteral obstruction1BeFree
umls:C0042510Ventricular Fibrillation1BeFree
umls:C0086692Benign Neoplasm1BeFree
umls:C0151546Oral Cavity Carcinoma1BeFree
umls:C0151744Myocardial Ischemia1BeFree
umls:C0153381Malignant neoplasm of mouth1BeFree
umls:C0153690Secondary malignant neoplasm of bone1BeFree
umls:C0178874Tumor Progression1BeFree
umls:C0178879Urinary tract obstruction1BeFree
umls:C0220641Lip and Oral Cavity Carcinoma1BeFree
umls:C0278488Carcinoma breast stage IV1BeFree
umls:C0280280stage, prostate cancer1BeFree
umls:C0280324Laryngeal Squamous Cell Carcinoma1BeFree
umls:C0346957Disseminated Malignant Neoplasm1BeFree
umls:C0409974Lupus Erythematosus1BeFree
umls:C0740391Middle Cerebral Artery Occlusion1BeFree
umls:C0917798Cerebral Ischemia1BeFree
umls:C0919267ovarian neoplasm1BeFree
umls:C0936223Metastatic Prostate Carcinoma1BeFree
umls:C1319315Adenocarcinoma of large intestine1BeFree
umls:C1368683Epithelioma1BeFree
umls:C1527249Colorectal Cancer1BeFree
umls:C1559271Non-Malignant Ascites Adverse Event1BeFree
umls:C1704272Benign Prostatic Hyperplasia1BeFree
umls:C2316810Chronic kidney disease stage 51BeFree
umls:C3714731Early childhood caries1BeFree
umls:C0399372Amelogenesis Imperfecta hypomaturation type0ORPHANET
umls:C1290537Amelogenesis imperfecta pigmented hypomaturation type0CTD_human
umls:C2673922Amelogenesis Imperfecta, Hypomaturation Type, Iia10CLINVAR