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| TissGeneSummary for KLK4 |
 Gene summary |
| Basic gene information | Gene symbol | KLK4 |
| Gene name | kallikrein-related peptidase 4 | |
| Synonyms | AI2A1|ARM1|EMSP|EMSP1|KLK-L1|PRSS17|PSTS|kallikrein | |
| Cytomap | UCSC genome browser: 19q13.41 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001302961.1, NM_004917.4,NR_126566.1, | |
| Description | androgen-regulated message 1enamel matrix serine protease 1enamel matrix serine proteinase 1kallikrein-4kallikrein-like protein 1prostaseserine protease 17 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603767 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000167749 | ||
| HPRD : 04793 | ||
| Vega : OTTHUMG00000182964 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KLK4 | |
| BioGPS: 9622 | ||
| Pathway | NCI Pathway Interaction Database: KLK4 | |
| KEGG: KLK4 | ||
| REACTOME: KLK4 | ||
| Pathway Commons: KLK4 | ||
| Context | iHOP: KLK4 | |
| ligand binding site mutation search in PubMed: KLK4 | ||
| UCL Cancer Institute: KLK4 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Prostate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRAD | |
| Reference showing the relevant tissue of KLK4 | Expression of human kallikrein 1-related peptidase 4 (KLK4) and MET phosphorylation in prostate cancer tissue: immunohistochemical analysis. Mukai S, Yorita K, Yamasaki K, Nagai T, Kamibeppu T, Sugie S, Kida K, Onizuka C, Tsukino H, Kamimura T, Kamoto T, Kataoka H. Hum Cell. 2015 Jul;28(3):133-42. doi: 10.1007/s13577-015-0114-6. Epub 2015 Apr 11. (pmid:25862631) go to article | |
| Description by TissGene annotations | Protective TissGene in RFS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for KLK4 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -2.229793591 | -3.569730846 | 1.339937255 | 3.14E-07 | 8.35E-07 |
| THCA | -0.798665342 | 2.171260081 | -2.969925424 | 6.97E-13 | 6.46E-12 |
| BRCA | 0.606485357 | -1.849958503 | 2.45644386 | 2.42E-20 | 1.77E-19 |
| KICH | 5.706447742 | -2.398076258 | 8.104524 | 7.55E-14 | 1.12E-12 |
| LIHC | -3.200580258 | -4.373992258 | 1.173412 | 0.00202 | 0.005144977 |
| PRAD | 9.60885705 | 8.095087819 | 1.513769231 | 9.32E-05 | 0.000393336 |
| Top |
| TissGene-miRNA for KLK4 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for KLK4 |
| TissGeneSNV for KLK4 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.T244S | LUAD | 1 |
| p.G34D | PRAD | 1 |
| p.G159S | STAD | 1 |
| p.T131N | UCEC | 1 |
| p.G219S | SKCM | 1 |
| p.A157V | UCEC | 1 |
| p.T143I | SKCM | 1 |
| p.A144E | LUAD | 1 |
| p.E35X | SKCM | 1 |
| p.G159S | ESCA | 1 |
| p.P39L | LUAD | 1 |
| p.L117F | SKCM | 1 |
| p.A88V | SKCM | 1 |
| p.A144T | PAAD | 1 |
| p.E51G | SKCM | 1 |
| p.G215R | SKCM | 1 |
| p.D116N | UCEC | 1 |
| p.V97M | UCEC | 1 |
| p.V164M | COAD | 1 |
| p.S102F | SKCM | 1 |
| p.G21* | UCEC | 1 |
| p.A70T | UCEC | 1 |
| p.A226S | BRCA | 1 |
| p.G159S | LGG | 1 |
| p.V150I | COAD | 1 |
| p.G215R | UCEC | 1 |
| p.P210A | STAD | 1 |
| p.L83P | STAD | 1 |
| p.V233M | UCEC | 1 |
| p.S22A | COAD | 1 |
| p.S139L | UCEC | 1 |
| p.C192* | HNSC | 1 |
| p.V150I | ESCA | 1 |
| p.Q95H | LUAD | 1 |
| p.C37Y | LGG | 1 |
| p.L117I | LGG | 1 |
| p.Q230H | ESCA | 1 |
| p.S139L | STAD | 1 |
| p.H40Q | PRAD | 1 |
| p.E53K | SKCM | 1 |
| p.S139L | READ | 1 |
| Top |
| TissGeneCNV for KLK4 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| Top |
| TissGeneFusions for KLK4 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BI020974 | KIF1C-KLK4 | chr17:4905402 | chr19:51410114 | |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-6499-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-J9-A52E-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-V1-A9Z8-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-J9-A52D-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-5515-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-ZG-A8QZ-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-XK-AAJ3-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-V1-A9Z7-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-6377-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-A9S4-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-CH-5769-11A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-TP-A8TV-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-7521-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-KK-A8IF-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-7325-01B | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-A6AL-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-A7NH-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-YL-A8SQ-01B | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-6339-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-7747-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-V1-A8ML-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-KC-A7FD-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-7519-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-Y6-A8TL-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-KK-A7AZ-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-KK-A7AP-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-7819-11A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-YL-A8HO-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-M7-A724-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-7738-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-XK-AAK1-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-J4-A67N-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-V1-A8MJ-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-6369-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-J4-A67L-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-7123-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-J4-8200-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-KC-A7FA-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-CH-5745-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-A65B-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-YL-A9WX-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-2A-AAYF-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-7213-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-5532-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-A76X-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-7525-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-X4-A8KQ-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-5494-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-KK-A8I5-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-XQ-A8TA-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-KK-A6E8-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-XJ-A9DK-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-CH-5772-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-CH-5748-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-CH-5746-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-V1-A9OY-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-7080-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-A65G-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-5527-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-MG-AAMC-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-V1-A8MM-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-V1-A9OH-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-YJ-A8SW-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-6336-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-5519-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-5517-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HI-7171-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-A7NF-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-VP-A875-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-7328-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-7820-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-6371-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-A8CY-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-ZG-A8QW-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-J4-A67M-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-KK-A6E0-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-7792-11A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-KK-A7B4-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-8258-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-6366-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-6385-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-7781-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-6338-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-6333-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-KK-A7B2-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-CH-5762-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-KK-A59V-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-KK-A5A1-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-YL-A8S8-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-8260-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-5503-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-KK-A6E7-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HI-7170-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-CH-5794-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-6351-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-7317-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-H9-7775-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-7210-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-FC-A8O0-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-XK-AAJA-01A | KLK4-PRSS36 | Out-of-Frame | chr19:51411834 | chr16:31155158 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AC-A5XU-01A | KAT6A-KLK4 | Out-of-frame | Chr8:41798360 | Chr19:51412085 |
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| TissGeneNet for KLK4 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| KLK4, SHBG, SERPINA3 (tumor) | KLK4, SHBG, SERPINA3 (normal) |
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| COAD (tumor) | COAD (normal) |
| KLK4, SHBG, SERPINA3 (tumor) | KLK4, SHBG, SERPINA3 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| KLK4, SHBG, SERPINA3 (tumor) | KLK4, SHBG, SERPINA3 (normal) |
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| KICH (tumor) | KICH (normal) |
| KLK4, SHBG, SERPINA3 (tumor) | KLK4, SHBG, SERPINA3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| KLK4, SHBG, SERPINA3 (tumor) | KLK4, SHBG, SERPINA3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| KLK4, SHBG, SERPINA3 (tumor) | KLK4, SHBG, SERPINA3 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| KLK4, SHBG, SERPINA3 (tumor) | KLK4, SHBG, SERPINA3 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| KLK4, SHBG, SERPINA3 (tumor) | KLK4, SHBG, SERPINA3 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| KLK4, SHBG, SERPINA3 (tumor) | KLK4, SHBG, SERPINA3 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| KLK4, SHBG, SERPINA3 (tumor) | KLK4, SHBG, SERPINA3 (normal) |
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| STAD (tumor) | STAD (normal) |
| KLK4, SHBG, SERPINA3 (tumor) | KLK4, SHBG, SERPINA3 (normal) |
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| THCA (tumor) | THCA (normal) |
| KLK4, SHBG, SERPINA3 (tumor) | KLK4, SHBG, SERPINA3 (normal) |
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| TissGeneProg for KLK4 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KLK4 |
| TissGeneDrug for KLK4 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KLK4 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0376358 | Malignant neoplasm of prostate | 24 | BeFree,GAD |
| umls:C0600139 | Prostate carcinoma | 22 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 15 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 14 | BeFree |
| umls:C0020538 | Hypertensive disease | 12 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 11 | BeFree,GAD |
| umls:C0033578 | Prostatic Neoplasms | 11 | BeFree,LHGDN |
| umls:C0678222 | Breast Carcinoma | 10 | BeFree |
| umls:C0002452 | Amelogenesis Imperfecta | 8 | BeFree,LHGDN |
| umls:C0022658 | Kidney Diseases | 5 | BeFree |
| umls:C0022116 | Ischemia | 3 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 3 | BeFree,LHGDN |
| umls:C0038454 | Cerebrovascular accident | 3 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 3 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 3 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 3 | BeFree,LHGDN |
| umls:C0007102 | Malignant tumor of colon | 2 | BeFree |
| umls:C0007103 | Malignant neoplasm of endometrium | 2 | BeFree |
| umls:C0007766 | Intracranial Aneurysm | 2 | BeFree |
| umls:C0007785 | Cerebral Infarction | 2 | BeFree |
| umls:C0022661 | Kidney Failure, Chronic | 2 | BeFree |
| umls:C0024141 | Lupus Erythematosus, Systemic | 2 | BeFree |
| umls:C0024143 | Lupus Nephritis | 2 | BeFree |
| umls:C0027051 | Myocardial Infarction | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C1883486 | Uterine Corpus Cancer | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
| umls:C0011269 | Dementia, Vascular | 1 | BeFree |
| umls:C0011991 | Diarrhea | 1 | BeFree |
| umls:C0018206 | granulosa cell tumor | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0023055 | Laryngeal neoplasm | 1 | BeFree |
| umls:C0023530 | Leukopenia | 1 | BeFree |
| umls:C0024131 | Lupus Vulgaris | 1 | BeFree |
| umls:C0024138 | Lupus Erythematosus, Discoid | 1 | BeFree |
| umls:C0027697 | Nephritis | 1 | BeFree |
| umls:C0027947 | Neutropenia | 1 | BeFree |
| umls:C0032002 | Pituitary Diseases | 1 | BeFree |
| umls:C0041956 | Ureteral obstruction | 1 | BeFree |
| umls:C0042510 | Ventricular Fibrillation | 1 | BeFree |
| umls:C0086692 | Benign Neoplasm | 1 | BeFree |
| umls:C0151546 | Oral Cavity Carcinoma | 1 | BeFree |
| umls:C0151744 | Myocardial Ischemia | 1 | BeFree |
| umls:C0153381 | Malignant neoplasm of mouth | 1 | BeFree |
| umls:C0153690 | Secondary malignant neoplasm of bone | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0178879 | Urinary tract obstruction | 1 | BeFree |
| umls:C0220641 | Lip and Oral Cavity Carcinoma | 1 | BeFree |
| umls:C0278488 | Carcinoma breast stage IV | 1 | BeFree |
| umls:C0280280 | stage, prostate cancer | 1 | BeFree |
| umls:C0280324 | Laryngeal Squamous Cell Carcinoma | 1 | BeFree |
| umls:C0346957 | Disseminated Malignant Neoplasm | 1 | BeFree |
| umls:C0409974 | Lupus Erythematosus | 1 | BeFree |
| umls:C0740391 | Middle Cerebral Artery Occlusion | 1 | BeFree |
| umls:C0917798 | Cerebral Ischemia | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | BeFree |
| umls:C0936223 | Metastatic Prostate Carcinoma | 1 | BeFree |
| umls:C1319315 | Adenocarcinoma of large intestine | 1 | BeFree |
| umls:C1368683 | Epithelioma | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C1559271 | Non-Malignant Ascites Adverse Event | 1 | BeFree |
| umls:C1704272 | Benign Prostatic Hyperplasia | 1 | BeFree |
| umls:C2316810 | Chronic kidney disease stage 5 | 1 | BeFree |
| umls:C3714731 | Early childhood caries | 1 | BeFree |
| umls:C0399372 | Amelogenesis Imperfecta hypomaturation type | 0 | ORPHANET |
| umls:C1290537 | Amelogenesis imperfecta pigmented hypomaturation type | 0 | CTD_human |
| umls:C2673922 | Amelogenesis Imperfecta, Hypomaturation Type, Iia1 | 0 | CLINVAR |
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