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| TissGeneSummary for FAM131B |
 Gene summary |
| Basic gene information | Gene symbol | FAM131B |
| Gene name | family with sequence similarity 131, member B | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 7q34 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001031690.2, NM_001278297.1,NM_014690.4, | |
| Description | protein FAM131B | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000159784 | ||
| HPRD : 13816 | ||
| Vega : OTTHUMG00000152697 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FAM131B | |
| BioGPS: 9715 | ||
| Pathway | NCI Pathway Interaction Database: FAM131B | |
| KEGG: FAM131B | ||
| REACTOME: FAM131B | ||
| Pathway Commons: FAM131B | ||
| Context | iHOP: FAM131B | |
| ligand binding site mutation search in PubMed: FAM131B | ||
| UCL Cancer Institute: FAM131B | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of FAM131B | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for FAM131B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -2.658067633 | -0.326347633 | -2.33172 | 5.29E-10 | 3.53E-09 |
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| TissGene-miRNA for FAM131B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FAM131B |
| TissGeneSNV for FAM131B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S200L | SKCM | 2 |
| p.S200P | LUAD | 1 |
| p.A335T | COAD | 1 |
| p.P74L | LUAD | 1 |
| p.T138M | ESCA | 1 |
| p.G80S | STAD | 1 |
| p.A335V | STAD | 1 |
| p.P298L | SKCM | 1 |
| p.Y141C | LIHC | 1 |
| p.E131K | SKCM | 1 |
| p.P240T | LUAD | 1 |
| p.G262R | SKCM | 1 |
| p.P289L | UCEC | 1 |
| p.S207N | SKCM | 1 |
| p.P215L | THCA | 1 |
| p.R338W | PAAD | 1 |
| p.P69L | UCEC | 1 |
| p.E233K | SKCM | 1 |
| p.M146I | SKCM | 1 |
| p.A142T | LUAD | 1 |
| p.A231V | UCEC | 1 |
| p.P215L | LUAD | 1 |
| p.Q126E | BRCA | 1 |
| p.E186K | SKCM | 1 |
| p.G108S | STAD | 1 |
| p.D204G | LIHC | 1 |
| p.M95K | SKCM | 1 |
| p.E198K | SKCM | 1 |
| p.R310W | PAAD | 1 |
| p.M67K | SKCM | 1 |
| p.E170K | SKCM | 1 |
| p.D208H | SKCM | 1 |
| p.A207S | LIHC | 1 |
| p.G92V | LUAD | 1 |
| p.D292N | SKCM | 1 |
| p.A170V | STAD | 1 |
| p.E354K | SKCM | 1 |
| p.S270A | LIHC | 1 |
| p.E120K | SARC | 1 |
| p.A265T | STAD | 1 |
| p.V157I | ESCA | 1 |
| p.E158K | SKCM | 1 |
| p.P95T | LUAD | 1 |
| p.L198Q | OV | 1 |
| p.S59L | SKCM | 1 |
| p.I14F | SKCM | 1 |
| p.E159K | SKCM | 1 |
| p.M172T | STAD | 1 |
| p.M211I | LUSC | 1 |
| p.A246G | OV | 1 |
| p.S235N | SKCM | 1 |
| p.H8N | LUAD | 1 |
| p.E233D | LUSC | 1 |
| p.H70Y | SKCM | 1 |
| p.V129I | ESCA | 1 |
| p.A203D | LUAD | 1 |
| p.G20D | BRCA | 1 |
| p.D137H | BRCA | 1 |
| p.A142V | STAD | 1 |
| p.E326K | SKCM | 1 |
| p.R107C | STAD | 1 |
| p.E205K | SKCM | 1 |
| p.S200L | HNSC | 1 |
| p.A207T | BRCA | 1 |
| p.E285K | SKCM | 1 |
| p.G290R | SKCM | 1 |
| p.A203V | SKCM | 1 |
| p.A179S | LIHC | 1 |
| p.A307V | STAD | 1 |
| p.G119S | OV | 1 |
| p.D236H | SKCM | 1 |
| p.M174I | SKCM | 1 |
| p.S228L | SKCM | 1 |
| p.R81G | LUAD | 1 |
| p.M77I | BLCA | 1 |
| p.Q239* | SKCM | 1 |
| p.P30H | UCEC | 1 |
| p.R135C | STAD | 1 |
| p.A213S | LUAD | 1 |
| p.F323S | SARC | 1 |
| p.E131Q | BLCA | 1 |
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| TissGeneCNV for FAM131B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FAM131B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | DA796945 | KIAA0247-FAM131B | chr14:70125394 | chr7:143051281 |
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| TissGeneNet for FAM131B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| FAM131B, TINF2, POT1, ACD (tumor) | FAM131B, TINF2, POT1, ACD (normal) |
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| COAD (tumor) | COAD (normal) |
| FAM131B, TINF2, POT1, ACD (tumor) | FAM131B, TINF2, POT1, ACD (normal) |
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| HNSC (tumor) | HNSC (normal) |
| FAM131B, TINF2, POT1, ACD (tumor) | FAM131B, TINF2, POT1, ACD (normal) |
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| KICH (tumor) | KICH (normal) |
| FAM131B, TINF2, POT1, ACD (tumor) | FAM131B, TINF2, POT1, ACD (normal) |
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| KIRC (tumor) | KIRC (normal) |
| FAM131B, TINF2, POT1, ACD (tumor) | FAM131B, TINF2, POT1, ACD (normal) |
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| KIRP (tumor) | KIRP (normal) |
| FAM131B, TINF2, POT1, ACD (tumor) | FAM131B, TINF2, POT1, ACD (normal) |
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| LIHC (tumor) | LIHC (normal) |
| FAM131B, TINF2, POT1, ACD (tumor) | FAM131B, TINF2, POT1, ACD (normal) |
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| LUAD (tumor) | LUAD (normal) |
| FAM131B, TINF2, POT1, ACD (tumor) | FAM131B, TINF2, POT1, ACD (normal) |
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| LUSC (tumor) | LUSC (normal) |
| FAM131B, TINF2, POT1, ACD (tumor) | FAM131B, TINF2, POT1, ACD (normal) |
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| PRAD (tumor) | PRAD (normal) |
| FAM131B, TINF2, POT1, ACD (tumor) | FAM131B, TINF2, POT1, ACD (normal) |
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| STAD (tumor) | STAD (normal) |
| FAM131B, TINF2, POT1, ACD (tumor) | FAM131B, TINF2, POT1, ACD (normal) |
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| THCA (tumor) | THCA (normal) |
| FAM131B, TINF2, POT1, ACD (tumor) | FAM131B, TINF2, POT1, ACD (normal) |
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| TissGeneProg for FAM131B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FAM131B |
| TissGeneDrug for FAM131B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FAM131B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1266177 | Dysembryoplastic neuroepithelial tumor | 2 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0334583 | Pilocytic Astrocytoma | 1 | BeFree |
| umls:C1997217 | Low grade glioma | 1 | BeFree |
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