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| TissGeneSummary for CDC25C |
 Gene summary |
| Basic gene information | Gene symbol | CDC25C |
| Gene name | cell division cycle 25C | |
| Synonyms | CDC25|PPP1R60 | |
| Cytomap | UCSC genome browser: 5q31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001287582.1, NM_001287583.1,NM_001790.4,NM_022809.3, | |
| Description | M-phase inducer phosphatase 3dual specificity phosphatase CDC25Cmitosis inducer CDC25phosphotyrosine phosphataseprotein phosphatase 1, regulatory subunit 60 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 157680 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000158402 | ||
| HPRD : 01146 | ||
| Vega : OTTHUMG00000129203 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CDC25C | |
| BioGPS: 995 | ||
| Pathway | NCI Pathway Interaction Database: CDC25C | |
| KEGG: CDC25C | ||
| REACTOME: CDC25C | ||
| Pathway Commons: CDC25C | ||
| Context | iHOP: CDC25C | |
| ligand binding site mutation search in PubMed: CDC25C | ||
| UCL Cancer Institute: CDC25C | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of CDC25C | ||
| Description by TissGene annotations | Cancer gene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CDC25C |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BLCA | 1.465059195 | -2.045767121 | 3.510826316 | 3.76E-06 | 9.40E-05 |
| PRAD | -1.729493538 | -3.571358922 | 1.841865385 | 1.45E-12 | 7.39E-11 |
| BRCA | 0.755626739 | -2.922697823 | 3.678324561 | 5.23E-54 | 7.37E-52 |
| LIHC | 0.445081616 | -3.782730384 | 4.227812 | 3.65E-25 | 7.37E-23 |
| STAD | 1.368590116 | -1.029059884 | 2.39765 | 5.61E-06 | 7.01E-05 |
| LUSC | 1.156245263 | -3.26053709 | 4.416782353 | 5.03E-35 | 6.29E-33 |
| HNSC | 0.930590407 | -0.596063082 | 1.526653488 | 2.63E-10 | 4.89E-09 |
| COAD | 1.950204539 | 0.667327616 | 1.282876923 | 3.42E-09 | 3.41E-08 |
| LUAD | 0.432648306 | -3.449124108 | 3.881772414 | 2.47E-30 | 3.08E-28 |
| KIRC | -1.634166828 | -4.283307106 | 2.649140278 | 1.20E-27 | 1.79E-26 |
| KIRP | -2.126047384 | -4.596841134 | 2.47079375 | 1.93E-09 | 1.71E-08 |
| ESCA | 1.180645798 | -2.140599657 | 3.321245455 | 0.000248 | 0.00599513 |
| KICH | -2.741512384 | -4.471504384 | 1.729992 | 6.06E-05 | 0.000165505 |
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| TissGene-miRNA for CDC25C |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CDC25C |
| TissGeneSNV for CDC25C |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P421L | SKCM | 2 |
| p.P421S | SKCM | 2 |
| p.S263F | BLCA | 1 |
| p.R461Q | DLBC | 1 |
| p.L33P | UCEC | 1 |
| p.D100N | LUAD | 1 |
| p.V374M | UCEC | 1 |
| p.P364L | SKCM | 1 |
| p.R331H | UCEC | 1 |
| p.Q430P | LUAD | 1 |
| p.G183E | SKCM | 1 |
| p.V452M | UCEC | 1 |
| p.H436Y | UCEC | 1 |
| p.R470C | STAD | 1 |
| p.R213C | SKCM | 1 |
| p.S93P | KICH | 1 |
| p.S75L | SKCM | 1 |
| p.L87H | LIHC | 1 |
| p.H437N | BRCA | 1 |
| p.H436N | CHOL | 1 |
| p.R386Q | COAD | 1 |
| p.K317T | STAD | 1 |
| p.L77R | SKCM | 1 |
| p.S17* | HNSC | 1 |
| p.P499L | LUSC | 1 |
| p.E393K | CESC | 1 |
| p.L93H | KIRC | 1 |
| p.S277C | LUAD | 1 |
| p.R461Q | LUAD | 1 |
| p.N278K | SKCM | 1 |
| p.R213H | STAD | 1 |
| p.P215Q | LUAD | 1 |
| p.E219D | READ | 1 |
| p.G280E | KIRP | 1 |
| p.E378* | UCEC | 1 |
| p.P361T | SARC | 1 |
| p.K369N | READ | 1 |
| p.T85I | SKCM | 1 |
| p.L54V | CESC | 1 |
| p.A91P | BLCA | 1 |
| p.E4K | HNSC | 1 |
| p.L111P | UCEC | 1 |
| p.S214F | SKCM | 1 |
| p.S7L | BRCA | 1 |
| p.V295M | COAD | 1 |
| p.L337R | SKCM | 1 |
| p.R213H | READ | 1 |
| p.E81D | LUAD | 1 |
| p.S238* | BRCA | 1 |
| p.D73N | STAD | 1 |
| p.G384S | SKCM | 1 |
| p.Q202* | SKCM | 1 |
| p.P218A | DLBC | 1 |
| p.R392C | STAD | 1 |
| p.C433F | KIRC | 1 |
| p.N222K | LIHC | 1 |
| p.L127V | STAD | 1 |
| p.P180S | HNSC | 1 |
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| TissGeneCNV for CDC25C |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CDC25C |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF911758 | LAT2-CDC25C | chr7:73639090 | chr5:137621106 | |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-E2-A15A-06A | CDC25C-ANKHD1-EIF4EBP3 | In-Frame | chr5:137661520 | chr5:139866644 |
| TCGAfusionPortal | PRADA | KIRC | TCGA-BP-5175-01A | PAIP2-CDC25C | 5UTR-CDS | Chr5:138677669 | Chr5:137627805 |
| TCGAfusionPortal | PRADA | PRAD | TCGA-CH-5740-01A | FAM13B-CDC25C | 5UTR-CDS | Chr5:137368471 | Chr5:137627805 |
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| TissGeneNet for CDC25C |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CDC25C, TP53, LCK, UBC, SRC, PLK1, YWHAQ, E2F4, NEDD4, CHEK1, YWHAE, CDK1, MAPK14, CHEK2, PCNA, MAPK3, CCNA2, CCNB1, PSME1, BRSK1, LZTS1 (tumor) | CDC25C, YWHAZ, HRAS, SRC, PLK1, YWHAQ, E2F4, NEDD4, CHEK1, YWHAE, CDK1, YWHAB, CHEK2, PCNA, YWHAH, CCNA2, CCNB1, MARK3, PLK3, PPP2R5D, LZTS1 (normal) |
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| COAD (tumor) | COAD (normal) |
| CDC25C, TP53, LCK, UBC, HRAS, PLK1, YWHAQ, E2F4, NEDD4, CHEK1, YWHAE, CDK1, CHEK2, PCNA, CCNA2, CCNB1, PSME1, PKN1, BRSK1, LZTS1, BRSK2 (tumor) | CDC25C, UBC, HRAS, MAPK1, PLK1, YWHAQ, E2F4, CHEK1, YWHAE, PIN1, CDK1, CHEK2, PCNA, CCNA2, CCNB1, PSME1, PKN1, PLK3, PPP2R5D, BRSK1, LZTS1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CDC25C, TP53, YWHAZ, HRAS, SRC, PLK1, YWHAQ, E2F4, CHEK1, CDK1, YWHAB, MAPK14, CHEK2, PCNA, MAPK3, CCNA2, CCNB1, PSME1, PKN1, BRSK1, BRSK2 (tumor) | CDC25C, TP53, LCK, YWHAZ, MAPK1, PLK1, NEDD4, CHEK1, YWHAE, PIN1, CDK1, MAPK14, CHEK2, PCNA, MAPK3, CCNA2, CCNB1, PSME1, MARK3, PLK3, PPP2R5D (normal) |
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| KICH (tumor) | KICH (normal) |
| CDC25C, TP53, LCK, YWHAZ, SRC, MAPK1, PLK1, E2F4, NEDD4, CDK1, YWHAB, CHEK2, PCNA, YWHAH, CCNA2, CCNB1, PSME1, PKN1, PLK3, BRSK1, LZTS1 (tumor) | CDC25C, TP53, UBC, YWHAZ, SRC, PLK1, E2F4, NEDD4, CHEK1, YWHAE, CDK1, YWHAB, CHEK2, PCNA, MAPK3, CCNA2, CCNB1, PKN1, PPP2R5D, BRSK1, BRSK2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CDC25C, TP53, LCK, YWHAZ, PLK1, YWHAQ, NEDD4, CHEK1, YWHAE, CDK1, YWHAB, MAPK14, CHEK2, PCNA, YWHAH, CCNA2, CCNB1, PLK3, PPP2R5D, BRSK1, LZTS1 (tumor) | CDC25C, TP53, LCK, UBC, YWHAZ, HRAS, SRC, MAPK1, PLK1, YWHAQ, E2F4, CHEK1, CDK1, CHEK2, PCNA, MAPK3, CCNA2, CCNB1, PSME1, BRSK1, BRSK2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CDC25C, TP53, LCK, YWHAZ, SRC, PLK1, CHEK1, YWHAE, PIN1, YWHAB, CHEK2, YWHAH, CCNA2, CCNB1, SRY, MARK3, PLK3, USP17L2, PPP2R5D, BRSK1, LZTS1 (tumor) | CDC25C, TP53, UBC, YWHAZ, HRAS, SRC, MAPK1, PLK1, E2F4, NEDD4, CHEK1, YWHAE, CDK1, CHEK2, PCNA, CCNA2, CCNB1, PSME1, PPP2R5D, LZTS1, BRSK2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CDC25C, LCK, YWHAZ, HRAS, SRC, PLK1, E2F4, CHEK1, CDK1, YWHAB, MAPK14, CHEK2, PCNA, MAPK3, CCNA2, CCNB1, PSME1, PLK3, PPP2R5D, BRSK1, LZTS1 (tumor) | CDC25C, YWHAZ, HRAS, SRC, PLK1, YWHAQ, NEDD4, CHEK1, CDK1, YWHAB, CHEK2, PCNA, YWHAH, MAPK3, CCNA2, CCNB1, PSME1, PKN1, PLK3, PPP2R5D, BRSK1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CDC25C, TP53, LCK, YWHAZ, HRAS, PLK1, YWHAQ, E2F4, NEDD4, CHEK1, PIN1, CDK1, YWHAB, CHEK2, PCNA, CCNA2, CCNB1, PSME1, MARK3, BRSK1, BRSK2 (tumor) | CDC25C, TP53, UBC, YWHAZ, HRAS, PLK1, YWHAQ, E2F4, CHEK1, YWHAE, CDK1, YWHAB, CHEK2, PCNA, YWHAH, CCNA2, CCNB1, PSME1, PLK3, PPP2R5D, BRSK1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CDC25C, TP53, LCK, UBC, YWHAZ, MAPK1, PLK1, CHEK1, YWHAE, PIN1, CDK1, MAPK14, CHEK2, PCNA, CCNA2, CCNB1, MARK3, PLK3, PPP2R5D, BRSK1, BRSK2 (tumor) | CDC25C, YWHAZ, PLK1, YWHAQ, NEDD4, CHEK1, YWHAE, CDK1, CHEK2, PCNA, YWHAH, MAPK3, CCNA2, CCNB1, PSME1, MARK3, PLK3, USP17L2, PPP2R5D, LZTS1, BRSK2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CDC25C, TP53, LCK, YWHAZ, PLK1, YWHAQ, E2F4, NEDD4, CHEK1, YWHAE, CDK1, CHEK2, PCNA, YWHAH, MAPK3, CCNA2, CCNB1, PSME1, PKN1, PPP2R5D, BRSK2 (tumor) | CDC25C, YWHAZ, HRAS, MAPK1, PLK1, YWHAQ, E2F4, NEDD4, CHEK1, YWHAE, PIN1, CDK1, CHEK2, PCNA, YWHAH, CCNA2, CCNB1, SRY, MARK3, PKN1, BRSK1 (normal) |
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| STAD (tumor) | STAD (normal) |
| CDC25C, TP53, LCK, SRC, MAPK1, PLK1, YWHAQ, E2F4, NEDD4, CHEK1, YWHAE, CDK1, MAPK14, CHEK2, PCNA, MAPK3, CCNA2, CCNB1, PSME1, BRSK1, BRSK2 (tumor) | CDC25C, YWHAZ, HRAS, SRC, MAPK1, PLK1, E2F4, NEDD4, CHEK1, YWHAE, CDK1, YWHAB, MAPK14, CHEK2, PCNA, CCNA2, CCNB1, PSME1, PPP2R5D, BRSK1, LZTS1 (normal) |
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| THCA (tumor) | THCA (normal) |
| CDC25C, TP53, LCK, MAPK1, PLK1, E2F4, NEDD4, CHEK1, YWHAE, CDK1, YWHAB, CHEK2, PCNA, YWHAH, MAPK3, CCNA2, CCNB1, PSME1, PKN1, PLK3, LZTS1 (tumor) | CDC25C, TP53, LCK, YWHAZ, HRAS, SRC, PLK1, E2F4, CHEK1, CDK1, MAPK14, CHEK2, PCNA, YWHAH, CCNA2, CCNB1, PSME1, PKN1, BRSK1, LZTS1, BRSK2 (normal) |
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| TissGeneProg for CDC25C |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CDC25C |
| TissGeneDrug for CDC25C |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CDC25C |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 7 | BeFree,GAD |
| umls:C0376358 | Malignant neoplasm of prostate | 6 | BeFree |
| umls:C0600139 | Prostate carcinoma | 6 | BeFree |
| umls:C0678222 | Breast Carcinoma | 6 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 4 | BeFree,GAD |
| umls:C2239176 | Liver carcinoma | 4 | BeFree |
| umls:C0004134 | Ataxia | 2 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
| umls:C0023418 | leukemia | 2 | BeFree |
| umls:C0023903 | Liver neoplasms | 2 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C0684249 | Carcinoma of lung | 2 | BeFree |
| umls:C0699790 | Colon Carcinoma | 2 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | GAD |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | BeFree |
| umls:C0010674 | Cystic Fibrosis | 1 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
| umls:C0017638 | Glioma | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0022680 | Polycystic Kidney Diseases | 1 | BeFree |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | GAD |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0024530 | Malaria | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0026764 | Multiple Myeloma | 1 | BeFree |
| umls:C0028326 | Noonan Syndrome | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0032019 | Pituitary Neoplasms | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
| umls:C0035335 | Retinoblastoma | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 1 | BeFree |
| umls:C0079744 | Diffuse Large B-Cell Lymphoma | 1 | BeFree |
| umls:C0153392 | Malignant neoplasm of nasopharynx | 1 | BeFree |
| umls:C0158683 | Polycystic liver disease | 1 | BeFree |
| umls:C0206624 | Hepatoblastoma | 1 | BeFree |
| umls:C0206638 | Giant Cell Tumor of Bone | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0238301 | Cancer of Nasopharynx | 1 | BeFree |
| umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 1 | BeFree |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C0345904 | Malignant neoplasm of liver | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0392164 | Pulmonary Cystic Fibrosis | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |
| umls:C2931822 | Nasopharyngeal carcinoma | 1 | BeFree |
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