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| TissGeneSummary for HS3ST2 |
 Gene summary |
| Basic gene information | Gene symbol | HS3ST2 |
| Gene name | heparan sulfate (glucosamine) 3-O-sulfotransferase 2 | |
| Synonyms | 30ST2|3OST2 | |
| Cytomap | UCSC genome browser: 16p12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006043.1, | |
| Description | 3-OST-2h3-OST-2heparan sulfate 3-O-sulfotransferase 2heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2heparan sulfate glucosamine 3-O-sulfotransferase 2heparin-glucosamine 3-O-sulfotransferase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604056 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000122254 | ||
| HPRD : 04957 | ||
| Vega : OTTHUMG00000094785 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HS3ST2 | |
| BioGPS: 9956 | ||
| Pathway | NCI Pathway Interaction Database: HS3ST2 | |
| KEGG: HS3ST2 | ||
| REACTOME: HS3ST2 | ||
| Pathway Commons: HS3ST2 | ||
| Context | iHOP: HS3ST2 | |
| ligand binding site mutation search in PubMed: HS3ST2 | ||
| UCL Cancer Institute: HS3ST2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainLung | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGLUAD,LUSC | |
| Reference showing the relevant tissue of HS3ST2 | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for HS3ST2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -0.060386636 | -3.90834358 | 3.847956944 | 6.83E-26 | 8.90E-25 |
| KICH | -1.178493525 | -3.888109525 | 2.709616 | 1.36E-06 | 5.04E-06 |
| LUSC | 0.09346075 | 1.926362711 | -1.832901961 | 1.59E-07 | 4.35E-07 |
| KIRP | 0.9656526 | -3.886650525 | 4.852303125 | 1.25E-09 | 1.16E-08 |
| STAD | -1.011706775 | -2.30226615 | 1.290559375 | 0.00221 | 0.009784035 |
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| TissGene-miRNA for HS3ST2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UVM | hsa-miR-218-5p | MIMAT0000275 | 0.0055 | -0.31 | 80 |
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| TissGeneMut for HS3ST2 |
| TissGeneSNV for HS3ST2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.V254M | STAD | 2 |
| p.R135X | SKCM | 1 |
| p.R48H | STAD | 1 |
| p.V202M | STAD | 1 |
| p.A267V | UCEC | 1 |
| p.P75L | SKCM | 1 |
| p.R346* | SKCM | 1 |
| p.T178M | COAD | 1 |
| p.E284K | STAD | 1 |
| p.P339H | UCEC | 1 |
| p.P188T | BLCA | 1 |
| p.S27L | BLCA | 1 |
| p.Y253* | HNSC | 1 |
| p.A142V | KIRC | 1 |
| p.V254M | LUAD | 1 |
| p.P265S | LUSC | 1 |
| p.K199E | BRCA | 1 |
| p.I225N | STAD | 1 |
| p.K108N | LUAD | 1 |
| p.I278V | LUAD | 1 |
| p.R210H | BRCA | 1 |
| p.D197G | LIHC | 1 |
| p.R249H | STAD | 1 |
| p.Q362* | BRCA | 1 |
| p.E347X | COAD | 1 |
| p.D363E | PAAD | 1 |
| p.R276* | UCEC | 1 |
| p.R324Q | SKCM | 1 |
| p.R190L | LIHC | 1 |
| p.E347X | READ | 1 |
| p.R210H | HNSC | 1 |
| p.G230S | SKCM | 1 |
| p.R210H | STAD | 1 |
| p.R324Q | KIRP | 1 |
| p.R196* | BLCA | 1 |
| p.E170Q | LUAD | 1 |
| p.L277H | KIRC | 1 |
| p.T174M | LUSC | 1 |
| p.R135* | SKCM | 1 |
| p.W260* | BLCA | 1 |
| p.R18H | ACC | 1 |
| p.P281L | STAD | 1 |
| p.R249C | SKCM | 1 |
| p.R141Q | PRAD | 1 |
| p.R113W | PAAD | 1 |
| p.D151G | COAD | 1 |
| p.G251S | SKCM | 1 |
| p.S220Y | LUAD | 1 |
| p.G121D | UCEC | 1 |
| p.G361W | LUAD | 1 |
| p.R205Q | OV | 1 |
| p.R324* | SKCM | 1 |
| p.A187T | PAAD | 1 |
| p.R54C | BLCA | 1 |
| p.R249C | UCEC | 1 |
| p.G310R | SKCM | 1 |
| p.D151E | ACC | 1 |
| p.P265S | SKCM | 1 |
| p.D338Y | THYM | 1 |
| p.A117D | LUAD | 1 |
| p.A282D | ACC | 1 |
| p.A17V | STAD | 1 |
| p.R346* | CESC | 1 |
| p.M285R | SKCM | 1 |
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| TissGeneCNV for HS3ST2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for HS3ST2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-85-7843-01A | VOPP1-HS3ST2 | Out-of-Frame | chr7:55559974 | chr16:22926264 |
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| TissGeneNet for HS3ST2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for HS3ST2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for HS3ST2 |
| TissGeneDrug for HS3ST2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for HS3ST2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007847 | Malignant tumor of cervix | 2 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
| umls:C0302592 | Cervix carcinoma | 2 | BeFree |
| umls:C0333875 | High-Grade Squamous Intraepithelial Lesions | 2 | BeFree |
| umls:C1527249 | Colorectal Cancer | 2 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0851140 | Carcinoma in situ of uterine cervix | 1 | BeFree |
| umls:C0853879 | Invasive breast carcinoma | 1 | BeFree |
| umls:C1334177 | Infiltrating Cervical Carcinoma | 1 | BeFree |
| umls:C3714514 | Infection | 1 | LHGDN |
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