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| TissGeneSummary for KCNE2 |
 Gene summary |
| Basic gene information | Gene symbol | KCNE2 |
| Gene name | potassium voltage-gated channel, Isk-related family, member 2 | |
| Synonyms | ATFB4|LQT5|LQT6|MIRP1 | |
| Cytomap | UCSC genome browser: 21q22.12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_172201.1, | |
| Description | cardiac voltage-gated potassium channel accessory subunit 2minK-related peptide 1minK-related peptide-1minimum potassium ion channel-related peptide 1potassium channel subunit beta MiRP1potassium channel subunit, MiRP1potassium voltage-gated channel | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 603796 | |
| HGNC : HGNC | ||
| HPRD : 04813 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KCNE2 | |
| BioGPS: 9992 | ||
| Pathway | NCI Pathway Interaction Database: KCNE2 | |
| KEGG: KCNE2 | ||
| REACTOME: KCNE2 | ||
| Pathway Commons: KCNE2 | ||
| Context | iHOP: KCNE2 | |
| ligand binding site mutation search in PubMed: KCNE2 | ||
| UCL Cancer Institute: KCNE2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Stomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STAD | |
| Reference showing the relevant tissue of KCNE2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0035690 | cellular response to drug | 10219239 | GO:0060306 | regulation of membrane repolarization | 10219239 | GO:0071435 | potassium ion export | 10219239 | GO:0071805 | potassium ion transmembrane transport | 10219239 | GO:0086009 | membrane repolarization | 10219239 | GO:1901379 | regulation of potassium ion transmembrane transport | 10219239 | GO:1901800 | positive regulation of proteasomal protein catabolic process | 22180649 | GO:1901979 | regulation of inward rectifier potassium channel activity | 10219239 | GO:1902259 | regulation of delayed rectifier potassium channel activity | 10219239 | GO:0035690 | cellular response to drug | 10219239 | GO:0060306 | regulation of membrane repolarization | 10219239 | GO:0071435 | potassium ion export | 10219239 | GO:0071805 | potassium ion transmembrane transport | 10219239 | GO:0086009 | membrane repolarization | 10219239 | GO:1901379 | regulation of potassium ion transmembrane transport | 10219239 | GO:1901800 | positive regulation of proteasomal protein catabolic process | 22180649 | GO:1901979 | regulation of inward rectifier potassium channel activity | 10219239 | GO:1902259 | regulation of delayed rectifier potassium channel activity | 10219239 |
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| TissGeneExp for KCNE2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | -1.967175636 | 0.327520518 | -2.294696154 | 3.22E-14 | 1.24E-12 |
| STAD | 0.417976047 | 2.937657297 | -2.51968125 | 0.00365 | 0.015089798 |
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| TissGene-miRNA for KCNE2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KCNE2 |
| TissGeneSNV for KCNE2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E94K | SKCM | 1 |
| p.A116V | KIRP | 1 |
| p.D42H | CESC | 1 |
| p.E90Q | BLCA | 1 |
| p.A43V | UCEC | 1 |
| p.Y22S | BLCA | 1 |
| p.I50L | SKCM | 1 |
| p.R77W | UCEC | 1 |
| p.N102I | UCEC | 1 |
| p.L51M | LUAD | 1 |
| p.E12A | UCEC | 1 |
| p.R77Q | PRAD | 1 |
| p.D91N | UCEC | 1 |
| p.E12D | UCEC | 1 |
| p.T71S | STAD | 1 |
| p.V49I | HNSC | 1 |
| p.X124R | KIRP | 1 |
| p.Y47F | BRCA | 1 |
| p.A116V | COAD | 1 |
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| TissGeneCNV for KCNE2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KCNE2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BRCA | TCGA-A8-A06U-01A | KCNE2-HTN3 | 5UTR-CDS | Chr21:35736450 | Chr4:70898884 |
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| TissGeneNet for KCNE2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| KCNE2, KCNQ1, KCNH2 (tumor) | KCNE2, KCNQ1, KCNH2 (normal) |
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| COAD (tumor) | COAD (normal) |
| KCNE2, KCNQ1, KCNH2 (tumor) | KCNE2, KCNQ1, KCNH2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| KCNE2, KCNQ1, KCNH2 (tumor) | KCNE2, KCNQ1, KCNH2 (normal) |
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| KICH (tumor) | KICH (normal) |
| KCNE2, KCNQ1, KCNH2 (tumor) | KCNE2, KCNQ1, KCNH2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| KCNE2, KCNQ1, KCNH2 (tumor) | KCNE2, KCNQ1, KCNH2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| KCNE2, KCNQ1, KCNH2 (tumor) | KCNE2, KCNQ1, KCNH2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| KCNE2, KCNQ1, KCNH2 (tumor) | KCNE2, KCNQ1, KCNH2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| KCNE2, KCNQ1, KCNH2 (tumor) | KCNE2, KCNQ1, KCNH2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| KCNE2, KCNQ1, KCNH2 (tumor) | KCNE2, KCNQ1, KCNH2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| KCNE2, KCNQ1, KCNH2 (tumor) | KCNE2, KCNQ1, KCNH2 (normal) |
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| STAD (tumor) | STAD (normal) |
| KCNE2, KCNQ1, KCNH2 (tumor) | KCNE2, KCNQ1, KCNH2 (normal) |
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| THCA (tumor) | THCA (normal) |
| KCNE2, KCNQ1, KCNH2 (tumor) | KCNE2, KCNQ1, KCNH2 (normal) |
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| TissGeneProg for KCNE2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KCNE2 |
| TissGeneDrug for KCNE2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KCNE2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0023976 | Long QT Syndrome | 40 | BeFree,CLINVAR,CTD_human,GAD |
| umls:C0522055 | Electrocardiogram abnormal | 7 | GAD |
| umls:C1141890 | Congenital long QT syndrome | 4 | BeFree,CLINVAR |
| umls:C0085298 | Sudden Cardiac Death | 3 | GAD |
| umls:C1142166 | Brugada Syndrome (disorder) | 3 | BeFree,GAD |
| umls:C3150953 | Long Qt Syndrome 6 | 3 | CLINVAR,CTD_human,UNIPROT |
| umls:C0003811 | Cardiac Arrhythmia | 2 | GAD,RGD |
| umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
| umls:C0035828 | Romano-Ward Syndrome | 2 | BeFree,ORPHANET |
| umls:C0232197 | Fibrillation | 2 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
| umls:C1563715 | Andersen Syndrome | 2 | BeFree |
| umls:C1720983 | Channelopathies | 2 | BeFree,GAD |
| umls:C1956346 | Coronary Artery Disease | 2 | BeFree,GAD |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0002871 | Anemia | 1 | BeFree |
| umls:C0004238 | Atrial Fibrillation | 1 | CTD_human,LHGDN |
| umls:C0004245 | Atrioventricular Block | 1 | GAD |
| umls:C0008628 | Chromosome Deletion | 1 | GAD |
| umls:C0010068 | Coronary heart disease | 1 | GAD |
| umls:C0011071 | Sudden death | 1 | GAD |
| umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | GAD |
| umls:C0013080 | Down Syndrome | 1 | CTD_human |
| umls:C0017152 | Gastritis | 1 | BeFree |
| umls:C0020676 | Hypothyroidism | 1 | BeFree |
| umls:C0027051 | Myocardial Infarction | 1 | GAD |
| umls:C0038644 | Sudden infant death syndrome | 1 | GAD |
| umls:C0039070 | Syncope | 1 | GAD |
| umls:C0040479 | Torsades de Pointes | 1 | GAD |
| umls:C0042510 | Ventricular Fibrillation | 1 | BeFree,CTD_human |
| umls:C0151786 | Muscle Weakness | 1 | CTD_human |
| umls:C0151878 | Prolonged QT interval | 1 | GAD |
| umls:C0152020 | Gastroparesis | 1 | GAD |
| umls:C0338480 | Common Migraine | 1 | GAD |
| umls:C0339789 | Congenital deafness | 1 | BeFree |
| umls:C0340489 | Lone atrial fibrillation | 1 | BeFree |
| umls:C0428908 | Sinus Node Dysfunction (disorder) | 1 | BeFree |
| umls:C0559758 | Multisystem disorder | 1 | BeFree |
| umls:C0878544 | Cardiomyopathies | 1 | GAD |
| umls:C1631597 | VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder) | 1 | BeFree |
| umls:C1862394 | Atrial Fibrillation, Familial, 4 | 1 | CLINVAR,CTD_human,UNIPROT |
| umls:C3698186 | Cardiac channelopathy | 1 | BeFree |
| umls:C0949658 | Cardiomyopathy, Hypertrophic, Familial | 0 | CLINVAR |
| umls:C1837014 | Atrial Fibrillation, Familial, 3 | 0 | CTD_human |
| umls:C1963067 | Atrial Fibrillation Adverse Event | 0 | CLINVAR |
| umls:C2732979 | Acquired long QT syndrome | 0 | CLINVAR |
| umls:C3150954 | LONG QT SYNDROME 6, ACQUIRED, SUSCEPTIBILITY TO | 0 | CLINVAR |
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