| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20067231 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
| TVIS20066328 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
| TVIS20021822 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
| TVIS20021828 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
| TVIS20013251 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
| TVIS20021829 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
| TVIS20026486 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
| TVIS20021821 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
| TVIS20021824 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
| TVIS20063911 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | JAK2 |
|---|---|
| DrugBank ID | DB11817 |
| Drug Name | Baricitinib |
| Target ID | BE0002408 |
| UniProt ID | O60674 |
| Regulation Type | inhibitor |
| PubMed IDs | 27028914; 28255337; 30871014 |
| Citations | Genovese MC, Kremer J, Zamani O, Ludivico C, Krogulec M, Xie L, Beattie SD, Koch AE, Cardillo TE, Rooney TP, Macias WL, de Bono S, Schlichting DE, Smolen JS: Baricitinib in Patients with Refractory Rheumatoid Arthritis. N Engl J Med. 2016 Mar 31;374(13):1243-52. doi: 10.1056/NEJMoa1507247.@@Kuriya B, Cohen MD, Keystone E: Baricitinib in rheumatoid arthritis: evidence-to-date and clinical potential. Ther Adv Musculoskelet Dis. 2017 Feb;9(2):37-44. doi: 10.1177/1759720X16687481. Epub 2017 Jan 23.@@Mayence A, Vanden Eynde JJ: Baricitinib: A 2018 Novel FDA-Approved Small Molecule Inhibiting Janus Kinases. Pharmaceuticals (Basel). 2019 Mar 12;12(1). pii: ph12010037. doi: 10.3390/ph12010037. |
| Groups | Approved; Investigational |
| Direct Classification | Pyrrolo[2,3-d]pyrimidines |
| SMILES | CCS(=O)(=O)N1CC(CC#N)(C1)N1C=C(C=N1)C1=C2C=CNC2=NC=N1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL2105759 |
