| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20067231 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
| TVIS20066328 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
| TVIS20021822 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
| TVIS20021828 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
| TVIS20013251 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
| TVIS20021829 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
| TVIS20026486 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
| TVIS20021821 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
| TVIS20021824 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
| TVIS20063911 | HPV | ENSG00000096968.14 | protein_coding | JAK2 | Yes | No | 3717 | O60674 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | JAK2 |
|---|---|
| DrugBank ID | DB12500 |
| Drug Name | Fedratinib |
| Target ID | BE0002408 |
| UniProt ID | O60674 |
| Regulation Type | inhibitor |
| PubMed IDs | 21220608; 27473820 |
| Citations | Pardanani A, Gotlib JR, Jamieson C, Cortes JE, Talpaz M, Stone RM, Silverman MH, Gilliland DG, Shorr J, Tefferi A: Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis. J Clin Oncol. 2011 Mar 1;29(7):789-96. doi: 10.1200/JCO.2010.32.8021. Epub 2011 Jan 10.@@Roskoski R Jr: Janus kinase (JAK) inhibitors in the treatment of inflammatory and neoplastic diseases. Pharmacol Res. 2016 Sep;111:784-803. doi: 10.1016/j.phrs.2016.07.038. Epub 2016 Jul 26. |
| Groups | Approved; Investigational |
| Direct Classification | Benzenesulfonamides |
| SMILES | CC1=CN=C(NC2=CC=C(OCCN3CCCC3)C=C2)N=C1NC1=CC=CC(=C1)S(=O)(=O)NC(C)(C)C |
| Pathways | |
| PharmGKB | PA166280361 |
| ChEMBL | CHEMBL1287853 |
