| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30013942 | HIV | ENSG00000105639.21 | protein_coding | JAK3 | Yes | No | 3718 | P52333 |
| TVIS30074295 | HIV | ENSG00000105639.21 | protein_coding | JAK3 | Yes | No | 3718 | P52333 |
| TVIS30048296 | HIV | ENSG00000105639.21 | protein_coding | JAK3 | Yes | No | 3718 | P52333 |
| TVIS30048297 | HIV | ENSG00000105639.21 | protein_coding | JAK3 | Yes | No | 3718 | P52333 |
| TVIS20007387 | HPV | ENSG00000105639.21 | protein_coding | JAK3 | Yes | No | 3718 | P52333 |
| TVIS20007388 | HPV | ENSG00000105639.21 | protein_coding | JAK3 | Yes | No | 3718 | P52333 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | JAK3 |
|---|---|
| DrugBank ID | DB15035 |
| Drug Name | Zanubrutinib |
| Target ID | BE0003493 |
| UniProt ID | P52333 |
| Regulation Type | inhibitor |
| PubMed IDs | 31381333 |
| Citations | Guo Y, Liu Y, Hu N, Yu D, Zhou C, Shi G, Zhang B, Wei M, Liu J, Luo L, Tang Z, Song H, Guo Y, Liu X, Su D, Zhang S, Song X, Zhou X, Hong Y, Chen S, Cheng Z, Young S, Wei Q, Wang H, Wang Q, Lv L, Wang F, Xu H, Sun H, Xing H, Li N, Zhang W, Wang Z, Liu G, Sun Z, Zhou D, Li W, Liu L, Wang L, Wang Z: Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase. J Med Chem. 2019 Sep 12;62(17):7923-7940. doi: 10.1021/acs.jmedchem.9b00687. Epub 2019 Aug 19. |
| Groups | Approved; Investigational |
| Direct Classification | Diphenylethers |
| SMILES | NC(=O)C1=C2NCC[C@@H](C3CCN(CC3)C(=O)C=C)N2N=C1C1=CC=C(OC2=CC=CC=C2)C=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL3936761 |
