| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30013942 | HIV | ENSG00000105639.21 | protein_coding | JAK3 | Yes | No | 3718 | P52333 |
| TVIS30074295 | HIV | ENSG00000105639.21 | protein_coding | JAK3 | Yes | No | 3718 | P52333 |
| TVIS30048296 | HIV | ENSG00000105639.21 | protein_coding | JAK3 | Yes | No | 3718 | P52333 |
| TVIS30048297 | HIV | ENSG00000105639.21 | protein_coding | JAK3 | Yes | No | 3718 | P52333 |
| TVIS20007387 | HPV | ENSG00000105639.21 | protein_coding | JAK3 | Yes | No | 3718 | P52333 |
| TVIS20007388 | HPV | ENSG00000105639.21 | protein_coding | JAK3 | Yes | No | 3718 | P52333 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | JAK3 |
|---|---|
| DrugBank ID | DB14924 |
| Drug Name | Ritlecitinib |
| Target ID | BE0003493 |
| UniProt ID | P52333 |
| Regulation Type | inhibitor |
| PubMed IDs | 36091777; 35210753; 27791347 |
| Citations | Yan D, Fan H, Chen M, Xia L, Wang S, Dong W, Wang Q, Niu S, Rao H, Chen L, Nie X, Fang Y: The efficacy and safety of JAK inhibitors for alopecia areata: A systematic review and meta-analysis of prospective studies. Front Pharmacol. 2022 Aug 24;13:950450. doi: 10.3389/fphar.2022.950450. eCollection 2022.@@Ramirez-Marin HA, Tosti A: Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata. Drug Des Devel Ther. 2022 Feb 17;16:363-374. doi: 10.2147/DDDT.S334727. eCollection 2022.@@Telliez JB, Dowty ME, Wang L, Jussif J, Lin T, Li L, Moy E, Balbo P, Li W, Zhao Y, Crouse K, Dickinson C, Symanowicz P, Hegen M, Banker ME, Vincent F, Unwalla R, Liang S, Gilbert AM, Brown MF, Hayward M, Montgomery J, Yang X, Bauman J, Trujillo JI, Casimiro-Garcia A, Vajdos FF, Leung L, Geoghegan KF, Quazi A, Xuan D, Jones L, Hett E, Wright K, Clark JD, Thorarensen A: Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition. ACS Chem Biol. 2016 Dec 16;11(12):3442-3451. doi: 10.1021/acschembio.6b00677. Epub 2016 Nov 10. |
| Groups | Approved; Investigational |
| Direct Classification | |
| SMILES | C[C@H]1CC[C@H](CN1C(=O)C=C)NC1=NC=NC2=C1C=CN2 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL4085457 |
