| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44018126 | HTLV-1 | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
| TVIS44014467 | HTLV-1 | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
| TVIS44014468 | HTLV-1 | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
| TVIS44036476 | HTLV-1 | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | BCL2 |
|---|---|
| DrugBank ID | DB12191 |
| Drug Name | Obatoclax |
| Target ID | BE0000246 |
| UniProt ID | P10415 |
| Regulation Type | |
| PubMed IDs | 17505826; 17227835 |
| Citations | Li J, Viallet J, Haura EB: A small molecule pan-Bcl-2 family inhibitor, GX15-070, induces apoptosis and enhances cisplatin-induced apoptosis in non-small cell lung cancer cells. Cancer Chemother Pharmacol. 2008 Mar;61(3):525-34. Epub 2007 May 16.@@Perez-Galan P, Roue G, Villamor N, Campo E, Colomer D: The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak. Blood. 2007 May 15;109(10):4441-9. Epub 2007 Jan 16. |
| Groups | Investigational |
| Direct Classification | Dipyrrins |
| SMILES | COC1=CC(=NC1=C/C1=C(C)C=C(C)N1)C1=CC2=CC=CC=C2N1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL408194 |
