| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44018126 | HTLV-1 | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
| TVIS44014467 | HTLV-1 | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
| TVIS44014468 | HTLV-1 | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
| TVIS44036476 | HTLV-1 | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | BCL2 |
|---|---|
| DrugBank ID | DB01367 |
| Drug Name | Rasagiline |
| Target ID | BE0000246 |
| UniProt ID | P10415 |
| Regulation Type | activator |
| PubMed IDs | 12043833; 12057839; 12200198; 14555244; 16148027 |
| Citations | Youdim MB, Weinstock M: Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]. Cell Mol Neurobiol. 2001 Dec;21(6):555-73.@@Akao Y, Maruyama W, Yi H, Shamoto-Nagai M, Youdim MB, Naoi M: An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic bcl-2 in human dopaminergic SH-SY5Y cells. Neurosci Lett. 2002 Jun 28;326(2):105-8.@@Maruyama W, Akao Y, Carrillo MC, Kitani K, Youdium MB, Naoi M: Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes. Neurotoxicol Teratol. 2002 Sep-Oct;24(5):675-82.@@Youdim MB, Amit T, Falach-Yogev M, Bar Am O, Maruyama W, Naoi M: The essentiality of Bcl-2, PKC and proteasome-ubiquitin complex activations in the neuroprotective-antiapoptotic action of the anti-Parkinson drug, rasagiline. Biochem Pharmacol. 2003 Oct 15;66(8):1635-41.@@Bar-Am O, Weinreb O, Amit T, Youdim MB: Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine. FASEB J. 2005 Nov;19(13):1899-901. Epub 2005 Sep 7. |
| Groups | Approved |
| Direct Classification | Indanes |
| SMILES | C#CCN[C@@H]1CCC2=CC=CC=C12 |
| Pathways | |
| PharmGKB | PA164764584 |
| ChEMBL | CHEMBL887 |
