| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44018126 | HTLV-1 | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
| TVIS44014467 | HTLV-1 | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
| TVIS44014468 | HTLV-1 | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
| TVIS44036476 | HTLV-1 | ENSG00000171791.14 | protein_coding | BCL2 | Yes | No | 596 | P10415 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | BCL2 |
|---|---|
| DrugBank ID | DB12340 |
| Drug Name | Navitoclax |
| Target ID | BE0000246 |
| UniProt ID | P10415 |
| Regulation Type | inhibitor |
| PubMed IDs | 25754349 |
| Citations | Hoffman-Luca CG, Ziazadeh D, McEachern D, Zhao Y, Sun W, Debussche L, Wang S: Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo. Clin Cancer Res. 2015 Jun 1;21(11):2558-68. doi: 10.1158/1078-0432.CCR-14-2506. Epub 2015 Mar 9. |
| Groups | Investigational |
| Direct Classification | Phenylpiperazines |
| SMILES | [H][C@@](CCN1CCOCC1)(CSC1=CC=CC=C1)NC1=C(C=C(C=C1)S(=O)(=O)NC(=O)C1=CC=C(C=C1)N1CCN(CC2=C(CCC(C)(C)C2)C2=CC=C(Cl)C=C2)CC1)S(=O)(=O)C(F)(F)F |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL443684 |
