| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44034617 | HTLV-1 | ENSG00000001626.18 | protein_coding | CFTR | No | No | 1080 | P13569 |
| TVIS44035802 | HTLV-1 | ENSG00000001626.18 | protein_coding | CFTR | No | No | 1080 | P13569 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | CFTR |
|---|---|
| DrugBank ID | DB08820 |
| Drug Name | Ivacaftor |
| Target ID | BE0001195 |
| UniProt ID | P13569 |
| Regulation Type | potentiator |
| PubMed IDs | 22293084; 27636560 |
| Citations | Yu H, Burton B, Huang CJ, Worley J, Cao D, Johnson JP Jr, Urrutia A, Joubran J, Seepersaud S, Sussky K, Hoffman BJ, Van Goor F: Ivacaftor potentiation of multiple CFTR channels with gating mutations. J Cyst Fibros. 2012 May;11(3):237-45. doi: 10.1016/j.jcf.2011.12.005. Epub 2012 Jan 30.@@Fohner AE, McDonagh EM, Clancy JP, Whirl Carrillo M, Altman RB, Klein TE: PharmGKB summary: ivacaftor pathway, pharmacokinetics/pharmacodynamics. Pharmacogenet Genomics. 2017 Jan;27(1):39-42. doi: 10.1097/FPC.0000000000000246. |
| Groups | Approved |
| Direct Classification | Aromatic anilides |
| SMILES | CC(C)(C)C1=CC(=C(O)C=C1NC(=O)C1=CNC2=CC=CC=C2C1=O)C(C)(C)C |
| Pathways | |
| PharmGKB | PA165950341 |
| ChEMBL | CHEMBL2010601 |
