| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44034617 | HTLV-1 | ENSG00000001626.18 | protein_coding | CFTR | No | No | 1080 | P13569 |
| TVIS44035802 | HTLV-1 | ENSG00000001626.18 | protein_coding | CFTR | No | No | 1080 | P13569 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CFTR |
|---|---|
| DrugBank ID | DB01016 |
| Drug Name | Glyburide |
| Target ID | BE0001195 |
| UniProt ID | P13569 |
| Regulation Type | antagonist |
| PubMed IDs | 12202948; 12391048; 12407077; 14729151; 15365090 |
| Citations | Reddy MM, Quinton PM: Effect of anion transport blockers on CFTR in the human sweat duct. J Membr Biol. 2002 Sep 1;189(1):15-25.@@Jiang J, Song Y, Bai C, Koller BH, Matthay MA, Verkman AS: Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrier. J Appl Physiol (1985). 2003 Jan;94(1):343-52. Epub 2002 Aug 30.@@Zhou Z, Hu S, Hwang TC: Probing an open CFTR pore with organic anion blockers. J Gen Physiol. 2002 Nov;120(5):647-62.@@Larsen EH, Amstrup J, Willumsen NJ: Beta-adrenergic receptors couple to CFTR chloride channels of intercalated mitochondria-rich cells in the heterocellular toad skin epithelium. Biochim Biophys Acta. 2003 Dec 30;1618(2):140-52.@@Lee SY, Lee CO: Inhibition of Na+-K+ pump and L-type Ca2+ channel by glibenclamide in Guinea pig ventricular myocytes. J Pharmacol Exp Ther. 2005 Jan;312(1):61-8. Epub 2004 Sep 13. |
| Groups | Approved |
| Direct Classification | Benzenesulfonamides |
| SMILES | COC1=C(C=C(Cl)C=C1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1 |
| Pathways | Glibenclamide Action Pathway |
| PharmGKB | PA449782 |
| ChEMBL | CHEMBL472 |
