| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44034617 | HTLV-1 | ENSG00000001626.18 | protein_coding | CFTR | No | No | 1080 | P13569 |
| TVIS44035802 | HTLV-1 | ENSG00000001626.18 | protein_coding | CFTR | No | No | 1080 | P13569 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | CFTR |
|---|---|
| DrugBank ID | DB11712 |
| Drug Name | Tezacaftor |
| Target ID | BE0001195 |
| UniProt ID | P13569 |
| Regulation Type | positive allosteric modulator |
| PubMed IDs | 28930490; 29099344; 27714410 |
| Citations | Donaldson SH, Pilewski JM, Griese M, Cooke J, Viswanathan L, Tullis E, Davies JC, Lekstrom-Himes JA, Wang LT: Tezacaftor/Ivacaftor in Subjects with Cystic Fibrosis and F508del/F508del-CFTR or F508del/G551D-CFTR. Am J Respir Crit Care Med. 2018 Jan 15;197(2):214-224. doi: 10.1164/rccm.201704-0717OC.@@Taylor-Cousar JL, Munck A, McKone EF, van der Ent CK, Moeller A, Simard C, Wang LT, Ingenito EP, McKee C, Lu Y, Lekstrom-Himes J, Elborn JS: Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del. N Engl J Med. 2017 Nov 23;377(21):2013-2023. doi: 10.1056/NEJMoa1709846. Epub 2017 Nov 3.@@Saint-Criq V, Gray MA: Role of CFTR in epithelial physiology. Cell Mol Life Sci. 2017 Jan;74(1):93-115. doi: 10.1007/s00018-016-2391-y. Epub 2016 Oct 6. |
| Groups | Approved; Investigational |
| Direct Classification | N-alkylindoles |
| SMILES | CC(C)(CO)C1=CC2=CC(NC(=O)C3(CC3)C3=CC=C4OC(F)(F)OC4=C3)=C(F)C=C2N1C[C@@H](O)CO |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL3544914 |
