| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20009341 | HPV | ENSG00000116478.13 | protein_coding | HDAC1 | Yes | No | 3065 | Q13547 Q6IT96 |
| TVIS20068329 | HPV | ENSG00000116478.13 | protein_coding | HDAC1 | Yes | No | 3065 | Q13547 Q6IT96 |
| TVIS44006869 | HTLV-1 | ENSG00000116478.13 | protein_coding | HDAC1 | Yes | No | 3065 | Q13547 Q6IT96 |
| TVIS44004202 | HTLV-1 | ENSG00000116478.13 | protein_coding | HDAC1 | Yes | No | 3065 | Q13547 Q6IT96 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | HDAC1 |
|---|---|
| DrugBank ID | DB06819 |
| Drug Name | Phenylbutyric acid |
| Target ID | BE0008667 |
| UniProt ID | Q9UKV0 |
| Regulation Type | inhibitor |
| PubMed IDs | 16391874; 12678732; 16000590; 24891937; 30562925 |
| Citations | Kouraklis G, Theocharis S: Histone deacetylase inhibitors: a novel target of anticancer therapy (review). Oncol Rep. 2006 Feb;15(2):489-94.@@Kouraklis G, Theocharis S: Histone deacetylase inhibitors and anticancer therapy. Curr Med Chem Anticancer Agents. 2002 Jul;2(4):477-84. doi: 10.2174/1568011023353921.@@Munshi A, Kurland JF, Nishikawa T, Tanaka T, Hobbs ML, Tucker SL, Ismail S, Stevens C, Meyn RE: Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity. Clin Cancer Res. 2005 Jul 1;11(13):4912-22. doi: 10.1158/1078-0432.CCR-04-2088.@@Ladiges W: The quality control theory of aging. Pathobiol Aging Age Relat Dis. 2014 May 23;4. pii: 24835. doi: 10.3402/pba.v4.24835. eCollection 2014.@@Chang MC, Chen YJ, Lian YC, Chang BE, Huang CC, Huang WL, Pan YH, Jeng JH: Butyrate Stimulates Histone H3 Acetylation, 8-Isoprostane Production, RANKL Expression, and Regulated Osteoprotegerin Expression/Secretion in MG-63 Osteoblastic Cells. Int J Mol Sci. 2018 Dec 17;19(12). pii: ijms19124071. doi: 10.3390/ijms19124071. |
| Groups | Approved; Investigational |
| Direct Classification | Benzene and substituted derivatives |
| SMILES | OC(=O)CCCC1=CC=CC=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL1469 |
