| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20009341 | HPV | ENSG00000116478.13 | protein_coding | HDAC1 | Yes | No | 3065 | Q13547 Q6IT96 |
| TVIS20068329 | HPV | ENSG00000116478.13 | protein_coding | HDAC1 | Yes | No | 3065 | Q13547 Q6IT96 |
| TVIS44006869 | HTLV-1 | ENSG00000116478.13 | protein_coding | HDAC1 | Yes | No | 3065 | Q13547 Q6IT96 |
| TVIS44004202 | HTLV-1 | ENSG00000116478.13 | protein_coding | HDAC1 | Yes | No | 3065 | Q13547 Q6IT96 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | HDAC1 |
|---|---|
| DrugBank ID | DB11841 |
| Drug Name | Entinostat |
| Target ID | BE0008667 |
| UniProt ID | Q9UKV0 |
| Regulation Type | inhibitor |
| PubMed IDs | 21282301; 16391874; 12411399; 12678732; 15843570; 22468166 |
| Citations | Dunoyer-Geindre S, Kruithof EK: Epigenetic control of tissue-type plasminogen activator synthesis in human endothelial cells. Cardiovasc Res. 2011 Jun 1;90(3):457-63. doi: 10.1093/cvr/cvr028. Epub 2011 Jan 31.@@Kouraklis G, Theocharis S: Histone deacetylase inhibitors: a novel target of anticancer therapy (review). Oncol Rep. 2006 Feb;15(2):489-94.@@Rossig L, Li H, Fisslthaler B, Urbich C, Fleming I, Forstermann U, Zeiher AM, Dimmeler S: Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis. Circ Res. 2002 Nov 1;91(9):837-44. doi: 10.1161/01.res.0000037983.07158.b1.@@Kouraklis G, Theocharis S: Histone deacetylase inhibitors and anticancer therapy. Curr Med Chem Anticancer Agents. 2002 Jul;2(4):477-84. doi: 10.2174/1568011023353921.@@Wang Y, Curry HM, Zwilling BS, Lafuse WP: Mycobacteria inhibition of IFN-gamma induced HLA-DR gene expression by up-regulating histone deacetylation at the promoter region in human THP-1 monocytic cells. J Immunol. 2005 May 1;174(9):5687-94. doi: 10.4049/jimmunol.174.9.5687.@@Huang PH, Plass C, Chen CS: Effects of Histone Deacetylase Inhibitors on Modulating H3K4 Methylation Marks - A Novel Cross-Talk Mechanism between Histone-Modifying Enzymes. Mol Cell Pharmacol. 2011;3(2):39-43. |
| Groups | Investigational |
| Direct Classification | Benzanilides |
| SMILES | NC1=CC=CC=C1NC(=O)C1=CC=C(CNC(=O)OCC2=CN=CC=C2)C=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL27759 |
