| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30079525 | HIV | ENSG00000165731.22 | protein_coding | RET | Yes | No | 5979 | P07949 |
| TVIS30027580 | HIV | ENSG00000165731.22 | protein_coding | RET | Yes | No | 5979 | P07949 |
| TVIS20046217 | HPV | ENSG00000165731.22 | protein_coding | RET | Yes | No | 5979 | P07949 |
| TVIS44026438 | HTLV-1 | ENSG00000165731.22 | protein_coding | RET | Yes | No | 5979 | P07949 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | RET |
|---|---|
| DrugBank ID | DB15822 |
| Drug Name | Pralsetinib |
| Target ID | BE0002411 |
| UniProt ID | P07949 |
| Regulation Type | inhibitor |
| PubMed IDs | 29657135 |
| Citations | Subbiah V, Gainor JF, Rahal R, Brubaker JD, Kim JL, Maynard M, Hu W, Cao Q, Sheets MP, Wilson D, Wilson KJ, DiPietro L, Fleming P, Palmer M, Hu MI, Wirth L, Brose MS, Ou SI, Taylor M, Garralda E, Miller S, Wolf B, Lengauer C, Guzi T, Evans EK: Precision Targeted Therapy with BLU-667 for RET-Driven Cancers. Cancer Discov. 2018 Jul;8(7):836-849. doi: 10.1158/2159-8290.CD-18-0338. Epub 2018 Apr 15. |
| Groups | Approved; Investigational |
| Direct Classification | |
| SMILES | CO[C@@]1(CC[C@@H](CC1)C1=NC(NC2=NNC(C)=C2)=CC(C)=N1)C(=O)N[C@@H](C)C1=CC=C(N=C1)N1C=C(F)C=N1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL4582651 |
