| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10058045 | HBV | ENSG00000164305.20 | protein_coding | CASP3 | No | No | 836 | P42574 |
| TVIS10058044 | HBV | ENSG00000164305.20 | protein_coding | CASP3 | No | No | 836 | P42574 |
| TVIS30008701 | HIV | ENSG00000164305.20 | protein_coding | CASP3 | No | No | 836 | P42574 |
| TVIS30008702 | HIV | ENSG00000164305.20 | protein_coding | CASP3 | No | No | 836 | P42574 |
| TVIS30061613 | HIV | ENSG00000164305.20 | protein_coding | CASP3 | No | No | 836 | P42574 |
| TVIS30061614 | HIV | ENSG00000164305.20 | protein_coding | CASP3 | No | No | 836 | P42574 |
| TVIS44019305 | HTLV-1 | ENSG00000164305.20 | protein_coding | CASP3 | No | No | 836 | P42574 |
| TVIS44019306 | HTLV-1 | ENSG00000164305.20 | protein_coding | CASP3 | No | No | 836 | P42574 |
| TVIS44004779 | HTLV-1 | ENSG00000164305.20 | protein_coding | CASP3 | No | No | 836 | P42574 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CASP3 |
|---|---|
| DrugBank ID | DB13048 |
| Drug Name | PAC-1 |
| Target ID | BE0001162 |
| UniProt ID | P42574 |
| Regulation Type | activator |
| PubMed IDs | 31943757; 19708658 |
| Citations | Huan LC, Anh DT, Truong BX, Duc PH, Hai PT, Duc-Anh L, Huong LT, Park EJ, Lee HJ, Kang JS, Tran PT, Thanh Hai DT, Kim Oanh DT, Han SB, Nam NH: New Acetohydrazides Incorporating 2-Oxoindoline and 4-Oxoquinazoline: Synthesis and Evaluation of Cytotoxicity and Caspase Activation Activity. Chem Biodivers. 2020 Mar;17(3):e1900670. doi: 10.1002/cbdv.201900670. Epub 2020 Feb 4.@@Peterson QP, Hsu DC, Goode DR, Novotny CJ, Totten RK, Hergenrother PJ: Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3. J Med Chem. 2009 Sep 24;52(18):5721-31. doi: 10.1021/jm900722z. |
| Groups | Investigational |
| Direct Classification | N-piperazineacetamides |
| SMILES | OC1=C(C=NNC(=O)CN2CCN(CC3=CC=CC=C3)CC2)C=CC=C1CC=C |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL591429 |
