| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10058045 | HBV | ENSG00000164305.20 | protein_coding | CASP3 | No | No | 836 | P42574 |
| TVIS10058044 | HBV | ENSG00000164305.20 | protein_coding | CASP3 | No | No | 836 | P42574 |
| TVIS30008701 | HIV | ENSG00000164305.20 | protein_coding | CASP3 | No | No | 836 | P42574 |
| TVIS30008702 | HIV | ENSG00000164305.20 | protein_coding | CASP3 | No | No | 836 | P42574 |
| TVIS30061613 | HIV | ENSG00000164305.20 | protein_coding | CASP3 | No | No | 836 | P42574 |
| TVIS30061614 | HIV | ENSG00000164305.20 | protein_coding | CASP3 | No | No | 836 | P42574 |
| TVIS44019305 | HTLV-1 | ENSG00000164305.20 | protein_coding | CASP3 | No | No | 836 | P42574 |
| TVIS44019306 | HTLV-1 | ENSG00000164305.20 | protein_coding | CASP3 | No | No | 836 | P42574 |
| TVIS44004779 | HTLV-1 | ENSG00000164305.20 | protein_coding | CASP3 | No | No | 836 | P42574 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CASP3 |
|---|---|
| DrugBank ID | DB01017 |
| Drug Name | Minocycline |
| Target ID | BE0001162 |
| UniProt ID | P42574 |
| Regulation Type | negative modulator |
| PubMed IDs | 10888929; 12112047; 14568022; 14588118; 15304547; 18977395 |
| Citations | Chen M, Ona VO, Li M, Ferrante RJ, Fink KB, Zhu S, Bian J, Guo L, Farrell LA, Hersch SM, Hobbs W, Vonsattel JP, Cha JH, Friedlander RM: Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med. 2000 Jul;6(7):797-801.@@Arvin KL, Han BH, Du Y, Lin SZ, Paul SM, Holtzman DM: Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury. Ann Neurol. 2002 Jul;52(1):54-61.@@Dommergues MA, Plaisant F, Verney C, Gressens P: Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection. Neuroscience. 2003;121(3):619-28.@@Lee SM, Yune TY, Kim SJ, Park DW, Lee YK, Kim YC, Oh YJ, Markelonis GJ, Oh TH: Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat. J Neurotrauma. 2003 Oct;20(10):1017-27.@@Baptiste DC, Hartwick AT, Jollimore CA, Baldridge WH, Seigel GM, Kelly ME: An investigation of the neuroprotective effects of tetracycline derivatives in experimental models of retinal cell death. Mol Pharmacol. 2004 Nov;66(5):1113-22. Epub 2004 Aug 10.@@Kim HS, Suh YH: Minocycline and neurodegenerative diseases. Behav Brain Res. 2009 Jan 23;196(2):168-79. doi: 10.1016/j.bbr.2008.09.040. Epub 2008 Oct 11. |
| Groups | Approved; Investigational |
| Direct Classification | Tetracyclines |
| SMILES | [H][C@@]12CC3=C(C(O)=CC=C3N(C)C)C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2 |
| Pathways | Minocycline Action Pathway |
| PharmGKB | PA450519 |
| ChEMBL | CHEMBL1434 |
