| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30060134 | HIV | ENSG00000109163.7 | protein_coding | GNRHR | No | No | 2798 | P30968 |
| TVIS30060135 | HIV | ENSG00000109163.7 | protein_coding | GNRHR | No | No | 2798 | P30968 |
| TVIS20009946 | HPV | ENSG00000109163.7 | protein_coding | GNRHR | No | No | 2798 | P30968 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | GNRHR |
|---|---|
| DrugBank ID | DB11979 |
| Drug Name | Elagolix |
| Target ID | BE0000203 |
| UniProt ID | P30968 |
| Regulation Type | antagonist |
| PubMed IDs | 19006286 |
| Citations | Chen C, Wu D, Guo Z, Xie Q, Reinhart GJ, Madan A, Wen J, Chen T, Huang CQ, Chen M, Chen Y, Tucci FC, Rowbottom M, Pontillo J, Zhu YF, Wade W, Saunders J, Bozigian H, Struthers RS: Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4 -methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor. J Med Chem. 2008 Dec 11;51(23):7478-85. doi: 10.1021/jm8006454. |
| Groups | Approved; Investigational |
| Direct Classification | Gamma amino acids and derivatives |
| SMILES | COC1=CC=CC(=C1F)C1=C(C)N(CC2=C(C=CC=C2F)C(F)(F)F)C(=O)N(C[C@H](NCCCC(O)=O)C2=CC=CC=C2)C1=O |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL1208155 |
