| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30000919 | HIV | ENSG00000100030.15 | protein_coding | MAPK1 | Yes | No | 5594 | P28482 Q1HBJ4 Q499G7 |
| TVIS30003372 | HIV | ENSG00000100030.15 | protein_coding | MAPK1 | Yes | No | 5594 | P28482 Q1HBJ4 Q499G7 |
| TVIS30008116 | HIV | ENSG00000100030.15 | protein_coding | MAPK1 | Yes | No | 5594 | P28482 Q1HBJ4 Q499G7 |
| TVIS30001152 | HIV | ENSG00000100030.15 | protein_coding | MAPK1 | Yes | No | 5594 | P28482 Q1HBJ4 Q499G7 |
| TVIS30003373 | HIV | ENSG00000100030.15 | protein_coding | MAPK1 | Yes | No | 5594 | P28482 Q1HBJ4 Q499G7 |
| TVIS30008117 | HIV | ENSG00000100030.15 | protein_coding | MAPK1 | Yes | No | 5594 | P28482 Q1HBJ4 Q499G7 |
| TVIS30083303 | HIV | ENSG00000100030.15 | protein_coding | MAPK1 | Yes | No | 5594 | P28482 Q1HBJ4 Q499G7 |
| TVIS30055141 | HIV | ENSG00000100030.15 | protein_coding | MAPK1 | Yes | No | 5594 | P28482 Q1HBJ4 Q499G7 |
| TVIS30055142 | HIV | ENSG00000100030.15 | protein_coding | MAPK1 | Yes | No | 5594 | P28482 Q1HBJ4 Q499G7 |
| TVIS30055143 | HIV | ENSG00000100030.15 | protein_coding | MAPK1 | Yes | No | 5594 | P28482 Q1HBJ4 Q499G7 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | MAPK1 |
|---|---|
| DrugBank ID | DB13930 |
| Drug Name | Ulixertinib |
| Target ID | BE0000923 |
| UniProt ID | P28482 |
| Regulation Type | inhibitor |
| PubMed IDs | 28939558 |
| Citations | Germann UA, Furey BF, Markland W, Hoover RR, Aronov AM, Roix JJ, Hale M, Boucher DM, Sorrell DA, Martinez-Botella G, Fitzgibbon M, Shapiro P, Wick MJ, Samadani R, Meshaw K, Groover A, DeCrescenzo G, Namchuk M, Emery CM, Saha S, Welsch DJ: Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib). Mol Cancer Ther. 2017 Nov;16(11):2351-2363. doi: 10.1158/1535-7163.MCT-17-0456. Epub 2017 Sep 22. |
| Groups | Investigational |
| Direct Classification | |
| SMILES | [H]N([C@H](CO)C1=CC(Cl)=CC=C1)C(=O)C1=CC(=CN1[H])C1=CC(=NC=C1Cl)N([H])C(C)C |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL3590106 |
