| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20004438 | HPV | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS20045653 | HPV | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS20051482 | HPV | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS44030090 | HTLV-1 | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS44020674 | HTLV-1 | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS44023481 | HTLV-1 | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS44010925 | HTLV-1 | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS44049507 | HTLV-1 | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SLC7A1 |
|---|---|
| DrugBank ID | DB00125 |
| Drug Name | Arginine |
| Target ID | BE0000212 |
| UniProt ID | P30825 |
| Regulation Type | |
| PubMed IDs | 17325243; 17329401; 17427197; 17065601; 17363779 |
| Citations | Yang Z, Venardos K, Jones E, Morris BJ, Chin-Dusting J, Kaye DM: Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction. Circulation. 2007 Mar 13;115(10):1269-74. Epub 2007 Feb 26.@@Rotmann A, Simon A, Martine U, Habermeier A, Closs EI: Activation of classical protein kinase C decreases transport via systems y+ and y+L. Am J Physiol Cell Physiol. 2007 Jun;292(6):C2259-68. Epub 2007 Feb 28.@@Vasquez R, Farias M, Vega JL, Martin RS, Vecchiola A, Casanello P, Sobrevia L: D-glucose stimulation of L-arginine transport and nitric oxide synthesis results from activation of mitogen-activated protein kinases p42/44 and Smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium. J Cell Physiol. 2007 Sep;212(3):626-32.@@Cerec V, Piquet-Pellorce C, Aly HA, Touzalin AM, Jegou B, Bauche F: Multiple pathways for cationic amino acid transport in rat seminiferous tubule cells. Biol Reprod. 2007 Feb;76(2):241-9. Epub 2006 Oct 25.@@Rotoli BM, Dall'asta V, Barilli A, D'Ippolito R, Tipa A, Olivieri D, Gazzola GC, Bussolati O: Alveolar macrophages from normal subjects lack the NOS-related system y+ for arginine transport. Am J Respir Cell Mol Biol. 2007 Jul;37(1):105-12. Epub 2007 Mar 15. |
| Groups | Investigational; Nutraceutical |
| Direct Classification | L-alpha-amino acids |
| SMILES | N[C@@H](CCCNC(N)=N)C(O)=O |
| Pathways | Citrullinemia Type I; Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency); Argininemia; Hyperornithinemia with Gyrate Atrophy (HOGA); Canavan Disease; Hypoacetylaspartia; Hyperprolinemia Type II; 3-Phosphoglycerate Dehydrogenase Deficiency; Non-Ketotic Hyperglycinemia; Argininosuccinic Aciduria; L-Arginine:Glycine Amidinotransferase Deficiency; Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome]; Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency); Prolidase Deficiency (PD); Glycine and Serine Metabolism; Hyperglycinemia, Non-Ketotic; Dimethylglycine Dehydrogenase Deficiency; Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency; Carbamoyl Phosphate Synthetase Deficiency; Ornithine Aminotransferase Deficiency (OAT Deficiency); Hyperprolinemia Type I; Dihydropyrimidine Dehydrogenase Deficiency (DHPD); Aspartate Metabolism; Nitric Oxide Signaling Pathway; Arginine and Proline Metabolism; Ornithine Transcarbamylase Deficiency (OTC Deficiency); Prolinemia Type II; Urea Cycle; Sarcosinemia |
| PharmGKB | PA448478 |
| ChEMBL | CHEMBL1485 |
