| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20004438 | HPV | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS20045653 | HPV | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS20051482 | HPV | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS44030090 | HTLV-1 | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS44020674 | HTLV-1 | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS44023481 | HTLV-1 | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS44010925 | HTLV-1 | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
| TVIS44049507 | HTLV-1 | ENSG00000139514.13 | protein_coding | SLC7A1 | No | No | 6541 | P30825 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SLC7A1 |
|---|---|
| DrugBank ID | DB00129 |
| Drug Name | Ornithine |
| Target ID | BE0000212 |
| UniProt ID | P30825 |
| Regulation Type | |
| PubMed IDs | 15491978; 17065601; 16703566; 17197568 |
| Citations | Rotmann A, Strand D, Martine U, Closs EI: Protein kinase C activation promotes the internalization of the human cationic amino acid transporter hCAT-1. A new regulatory mechanism for hCAT-1 activity. J Biol Chem. 2004 Dec 24;279(52):54185-92. Epub 2004 Oct 15.@@Cerec V, Piquet-Pellorce C, Aly HA, Touzalin AM, Jegou B, Bauche F: Multiple pathways for cationic amino acid transport in rat seminiferous tubule cells. Biol Reprod. 2007 Feb;76(2):241-9. Epub 2006 Oct 25.@@Yeramian A, Martin L, Arpa L, Bertran J, Soler C, McLeod C, Modolell M, Palacin M, Lloberas J, Celada A: Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation. Eur J Immunol. 2006 Jun;36(6):1516-26.@@Kaneko S, Ando A, Okuda-Ashitaka E, Maeda M, Furuta K, Suzuki M, Matsumura M, Ito S: Ornithine transport via cationic amino acid transporter-1 is involved in ornithine cytotoxicity in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2007 Jan;48(1):464-71. |
| Groups | Approved; Nutraceutical |
| Direct Classification | L-alpha-amino acids |
| SMILES | NCCC[C@H](N)C(O)=O |
| Pathways | Citrullinemia Type I; Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency); Argininemia; Hyperornithinemia with Gyrate Atrophy (HOGA); Spermidine and Spermine Biosynthesis; Hyperprolinemia Type II; Argininosuccinic Aciduria; L-Arginine:Glycine Amidinotransferase Deficiency; Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome]; Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency); Prolidase Deficiency (PD); Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency; Carbamoyl Phosphate Synthetase Deficiency; Ornithine Aminotransferase Deficiency (OAT Deficiency); Hyperprolinemia Type I; Arginine and Proline Metabolism; Ornithine Transcarbamylase Deficiency (OTC Deficiency); Prolinemia Type II; Urea Cycle |
| PharmGKB | PA164783814 |
| ChEMBL | CHEMBL446143 |
