| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30016613 | HIV | ENSG00000104549.12 | protein_coding | SQLE | No | No | 6713 | Q14534 Q9UNR6 |
| TVIS30016614 | HIV | ENSG00000104549.12 | protein_coding | SQLE | No | No | 6713 | Q14534 Q9UNR6 |
| TVIS30021692 | HIV | ENSG00000104549.12 | protein_coding | SQLE | No | No | 6713 | Q14534 Q9UNR6 |
| TVIS30069809 | HIV | ENSG00000104549.12 | protein_coding | SQLE | No | No | 6713 | Q14534 Q9UNR6 |
| TVIS30069810 | HIV | ENSG00000104549.12 | protein_coding | SQLE | No | No | 6713 | Q14534 Q9UNR6 |
| TVIS30069811 | HIV | ENSG00000104549.12 | protein_coding | SQLE | No | No | 6713 | Q14534 Q9UNR6 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SQLE |
|---|---|
| DrugBank ID | DB00857 |
| Drug Name | Terbinafine |
| Target ID | BE0000577 |
| UniProt ID | Q14534 |
| Regulation Type | inhibitor |
| PubMed IDs | 12100530; 12226513; 12477372; 12963042; 14638499; 11752352; 1543672; 19874252 |
| Citations | Sander CS, Hipler UC, Wollina U, Elsner P: Inhibitory effect of terbinafine on reactive oxygen species (ROS) generation by Candida albicans. Mycoses. 2002 Jun;45(5-6):152-5.@@Wentzinger LF, Bach TJ, Hartmann MA: Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase. Plant Physiol. 2002 Sep;130(1):334-46.@@Darkes MJ, Scott LJ, Goa KL: Terbinafine: a review of its use in onychomycosis in adults. Am J Clin Dermatol. 2003;4(1):39-65.@@Klobucnikova V, Kohut P, Leber R, Fuchsbichler S, Schweighofer N, Turnowsky F, Hapala I: Terbinafine resistance in a pleiotropic yeast mutant is caused by a single point mutation in the ERG1 gene. Biochem Biophys Res Commun. 2003 Sep 26;309(3):666-71.@@Leber R, Fuchsbichler S, Klobucnikova V, Schweighofer N, Pitters E, Wohlfarter K, Lederer M, Landl K, Ruckenstuhl C, Hapala I, Turnowsky F: Molecular mechanism of terbinafine resistance in Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2003 Dec;47(12):3890-900.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Ryder NS: Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol. 1992 Feb;126 Suppl 39:2-7.@@Krishnan-Natesan S: Terbinafine: a pharmacological and clinical review. Expert Opin Pharmacother. 2009 Nov;10(16):2723-33. doi: 10.1517/14656560903307462. |
| Groups | Approved; Investigational; Vet_approved |
| Direct Classification | Naphthalenes |
| SMILES | CN(CC=CC#CC(C)(C)C)CC1=CC=CC2=CC=CC=C12 |
| Pathways | |
| PharmGKB | PA451614 |
| ChEMBL | CHEMBL822 |
