| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30084527 | HIV | ENSG00000143839.15 | protein_coding | REN | No | No | 5972 | P00797 |
| TVIS20008388 | HPV | ENSG00000143839.15 | protein_coding | REN | No | No | 5972 | P00797 |
| TVIS44024466 | HTLV-1 | ENSG00000143839.15 | protein_coding | REN | No | No | 5972 | P00797 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | REN |
|---|---|
| DrugBank ID | DB09026 |
| Drug Name | Aliskiren |
| Target ID | BE0000270 |
| UniProt ID | P00797 |
| Regulation Type | inhibitor |
| PubMed IDs | 11799102; 12927775; 16467656; 16508564; 16965731; 21687346 |
| Citations | Nussberger J, Wuerzner G, Jensen C, Brunner HR: Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalapril. Hypertension. 2002 Jan;39(1):E1-8.@@Wood JM, Maibaum J, Rahuel J, Grutter MG, Cohen NC, Rasetti V, Ruger H, Goschke R, Stutz S, Fuhrer W, Schilling W, Rigollier P, Yamaguchi Y, Cumin F, Baum HP, Schnell CR, Herold P, Mah R, Jensen C, O'Brien E, Stanton A, Bedigian MP: Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun. 2003 Sep 5;308(4):698-705.@@Menard J, Guyene TT, Peyrard S, Azizi M: Conformational changes in prorenin during renin inhibition in vitro and in vivo. J Hypertens. 2006 Mar;24(3):529-34.@@Azizi M, Webb R, Nussberger J, Hollenberg NK: Renin inhibition with aliskiren: where are we now, and where are we going? J Hypertens. 2006 Feb;24(2):243-56.@@Gradman AH, Vivas Y: New drugs for hypertension: what do they offer? Curr Hypertens Rep. 2006 Oct;8(5):425-32.@@Wal P, Wal A, Rai AK, Dixit A: Aliskiren: An orally active renin inhibitor. J Pharm Bioallied Sci. 2011 Apr;3(2):189-93. doi: 10.4103/0975-7406.80764. |
| Groups | Approved; Investigational |
| Direct Classification | Delta amino acids and derivatives |
| SMILES | COCCCOC1=C(OC)C=CC(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)=C1 |
| Pathways | |
| PharmGKB | PA143487910 |
| ChEMBL | CHEMBL1639 |
