| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10009167 | HBV | ENSG00000183873.20 | protein_coding | SCN5A | No | No | 6331 | E9PG18 E9PHB6 H9KVD2 K4DIA1 Q14524 Q86V90 |
| TVIS20012030 | HPV | ENSG00000183873.20 | protein_coding | SCN5A | No | No | 6331 | E9PG18 E9PHB6 H9KVD2 K4DIA1 Q14524 Q86V90 |
| TVIS20036049 | HPV | ENSG00000183873.20 | protein_coding | SCN5A | No | No | 6331 | E9PG18 E9PHB6 H9KVD2 K4DIA1 Q14524 Q86V90 |
| TVIS20056806 | HPV | ENSG00000183873.20 | protein_coding | SCN5A | No | No | 6331 | E9PG18 E9PHB6 H9KVD2 K4DIA1 Q14524 Q86V90 |
| TVIS44025067 | HTLV-1 | ENSG00000183873.20 | protein_coding | SCN5A | No | No | 6331 | E9PG18 E9PHB6 H9KVD2 K4DIA1 Q14524 Q86V90 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SCN5A |
|---|---|
| DrugBank ID | DB01346 |
| Drug Name | Quinidine barbiturate |
| Target ID | BE0000197 |
| UniProt ID | Q14524 |
| Regulation Type | inhibitor |
| PubMed IDs | 17023504; 15877619; 16138883; 16972995; 17556186; 11752352; 20685573; 9476974 |
| Citations | Stokoe KS, Thomas G, Goddard CA, Colledge WH, Grace AA, Huang CL: Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/Delta murine hearts modelling long QT syndrome 3. J Physiol. 2007 Jan 1;578(Pt 1):69-84. Epub 2006 Oct 5.@@Itoh H, Shimizu M, Takata S, Mabuchi H, Imoto K: A novel missense mutation in the SCN5A gene associated with Brugada syndrome bidirectionally affecting blocking actions of antiarrhythmic drugs. J Cardiovasc Electrophysiol. 2005 May;16(5):486-93.@@Grant AO: Electrophysiological basis and genetics of Brugada syndrome. J Cardiovasc Electrophysiol. 2005 Sep;16 Suppl 1:S3-7.@@Napolitano C, Priori SG: Brugada syndrome. Orphanet J Rare Dis. 2006 Sep 14;1:35.@@Ohgo T, Okamura H, Noda T, Satomi K, Suyama K, Kurita T, Aihara N, Kamakura S, Ohe T, Shimizu W: Acute and chronic management in patients with Brugada syndrome associated with electrical storm of ventricular fibrillation. Heart Rhythm. 2007 Jun;4(6):695-700. Epub 2007 Feb 20.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Sheets MF, Fozzard HA, Lipkind GM, Hanck DA: Sodium channel molecular conformations and antiarrhythmic drug affinity. Trends Cardiovasc Med. 2010 Jan;20(1):16-21. doi: 10.1016/j.tcm.2010.03.002.@@Tella SR, Goldberg SR: Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine. Pharmacol Biochem Behav. 1998 Feb;59(2):305-12. |
| Groups | Approved |
| Direct Classification | Cinchona alkaloids |
| SMILES | CCC1(C(=O)NC(=O)NC1=O)C1=CC=CC=C1.COC1=CC2=C(C=CN=C2C=C1)C(O)C1CC2CCN1CC2C=C |
| Pathways | |
| PharmGKB | PA164783957 |
| ChEMBL |
