| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10007745 | HBV | ENSG00000144891.19 | protein_coding | AGTR1 | No | No | 185 | A0A0A0MSE3 D3DNG8 P30556 Q53YY0 Q6NUP5 |
| TVIS10041838 | HBV | ENSG00000144891.19 | protein_coding | AGTR1 | No | No | 185 | A0A0A0MSE3 D3DNG8 P30556 Q53YY0 Q6NUP5 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | AGTR1 |
|---|---|
| DrugBank ID | DB00678 |
| Drug Name | Losartan |
| Target ID | BE0000062 |
| UniProt ID | P30556 |
| Regulation Type | antagonist |
| PubMed IDs | 11752352; 15026875; 15991937; 12710529; 12719755; 15573751 |
| Citations | Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Sardo MA, Castaldo M, Cinquegrani M, Bonaiuto M, Fontana L, Campo S, Campo GM, Altavilla D, Saitta A: Effects of AT1 receptor antagonist losartan on sICAM-1 and TNF-alpha levels in uncomplicated hypertensive patients. Angiology. 2004 Mar-Apr;55(2):195-203.@@Dickstein K, Timmermans P, Segal R: Losartan: a selective angiotensin II type 1 (AT1) receptor antagonist for the treatment of heart failure. Expert Opin Investig Drugs. 1998 Nov;7(11):1897-914.@@Anand-Srivastava MB, Palaparti A: Angiotensin-II-induced enhanced expression of Gi proteins is attenuated by losartan in A10 vascular smooth muscle cells: role of AT1 receptors. Can J Physiol Pharmacol. 2003 Feb;81(2):150-8.@@Rocha I, Bras-Rosario L, Amparo-Barros M, Silva-Carvalho L: Angiotensin AT1 receptor antagonist losartan and the defence reaction in the anaesthetised rat. Effect on the carotid chemoreflex. Exp Physiol. 2003 May;88(3):309-14.@@Guan J, Cheng DY, Chen XJ, Zhang Y, Wang H, Su QL: [The effects of losartan on pulmonary arterial collagen and AT1 in chronic hypoxic rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2004 Nov;35(6):774-7. |
| Groups | Approved |
| Direct Classification | Biphenyls and derivatives |
| SMILES | CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=C1)C1=CC=CC=C1C1=NNN=N1 |
| Pathways | Losartan Action Pathway |
| PharmGKB | PA450268 |
| ChEMBL | CHEMBL191 |
