| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10036751 | HBV | ENSG00000136160.17 | protein_coding | EDNRB | No | No | 1910 | P24530 |
| TVIS10050050 | HBV | ENSG00000136160.17 | protein_coding | EDNRB | No | No | 1910 | P24530 |
| TVIS30035474 | HIV | ENSG00000136160.17 | protein_coding | EDNRB | No | No | 1910 | P24530 |
| TVIS20046672 | HPV | ENSG00000136160.17 | protein_coding | EDNRB | No | No | 1910 | P24530 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | EDNRB |
|---|---|
| DrugBank ID | DB06268 |
| Drug Name | Sitaxentan |
| Target ID | BE0000043 |
| UniProt ID | P24530 |
| Regulation Type | antagonist |
| PubMed IDs | 17472992; 11752352; 7921608; 16335785; 9806221; 7858879; 15629255 |
| Citations | Girgis RE, Frost AE, Hill NS, Horn EM, Langleben D, McLaughlin VV, Oudiz RJ, Robbins IM, Seibold JR, Shapiro S, Tapson VF, Barst RJ: Selective endothelin A receptor antagonism with sitaxsentan for pulmonary arterial hypertension associated with connective tissue disease. Ann Rheum Dis. 2007 Nov;66(11):1467-72. Epub 2007 May 1.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Gardiner SM, Kemp PA, March JE, Bennett T: Effects of bosentan (Ro 47-0203), an ETA-, ETB-receptor antagonist, on regional haemodynamic responses to endothelins in conscious rats. Br J Pharmacol. 1994 Jul;112(3):823-30.@@Gupta SK, Saxena A, Singh U, Arya DS: Bosentan, the mixed ETA-ETB endothelin receptor antagonist, attenuated oxidative stress after experimental myocardial ischemia and reperfusion. Mol Cell Biochem. 2005 Jul;275(1-2):67-74.@@Marano G, Palazzesi S, Bernucci P, Grigioni M, Formigari R, Ballerini L: ET(A)/ET(B) receptor antagonist bosentan inhibits neointimal development in collared carotid arteries of rabbits. Life Sci. 1998;63(18):PL259-66.@@Richard V, Kaeffer N, Hogie M, Tron C, Blanc T, Thuillez C: Role of endogenous endothelin in myocardial and coronary endothelial injury after ischaemia and reperfusion in rats: studies with bosentan, a mixed ETA-ETB antagonist. Br J Pharmacol. 1994 Nov;113(3):869-76.@@Said SA, Ammar el SM, Suddek GM: Effect of bosentan (ETA/ETB receptor antagonist) on metabolic changes during stress and diabetes. Pharmacol Res. 2005 Feb;51(2):107-15. |
| Groups | Approved; Investigational; Withdrawn |
| Direct Classification | Benzodioxoles |
| SMILES | CC1=NOC(NS(=O)(=O)C2=C(SC=C2)C(=O)CC2=CC3=C(OCO3)C=C2C)=C1Cl |
| Pathways | |
| PharmGKB | PA165958361 |
| ChEMBL | CHEMBL282724 |
