| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10006324 | HBV | ENSG00000160752.15 | protein_coding | FDPS | No | No | 2224 | A0A087X090 P14324 |
| TVIS10003145 | HBV | ENSG00000160752.15 | protein_coding | FDPS | No | No | 2224 | A0A087X090 P14324 |
| TVIS10022102 | HBV | ENSG00000160752.15 | protein_coding | FDPS | No | No | 2224 | A0A087X090 P14324 |
| TVIS10025984 | HBV | ENSG00000160752.15 | protein_coding | FDPS | No | No | 2224 | A0A087X090 P14324 |
| TVIS10051965 | HBV | ENSG00000160752.15 | protein_coding | FDPS | No | No | 2224 | A0A087X090 P14324 |
| TVIS10052093 | HBV | ENSG00000160752.15 | protein_coding | FDPS | No | No | 2224 | A0A087X090 P14324 |
| TVIS30025272 | HIV | ENSG00000160752.15 | protein_coding | FDPS | No | No | 2224 | A0A087X090 P14324 |
| TVIS30025273 | HIV | ENSG00000160752.15 | protein_coding | FDPS | No | No | 2224 | A0A087X090 P14324 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | FDPS |
|---|---|
| DrugBank ID | DB00630 |
| Drug Name | Alendronic acid |
| Target ID | BE0000776 |
| UniProt ID | P14324 |
| Regulation Type | inhibitor |
| PubMed IDs | 10620343; 11752352; 11160603; 17535895 |
| Citations | Bergstrom JD, Bostedor RG, Masarachia PJ, Reszka AA, Rodan G: Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. Arch Biochem Biophys. 2000 Jan 1;373(1):231-41.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Dunford JE, Thompson K, Coxon FP, Luckman SP, Hahn FM, Poulter CD, Ebetino FH, Rogers MJ: Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther. 2001 Feb;296(2):235-42.@@Guo RT, Cao R, Liang PH, Ko TP, Chang TH, Hudock MP, Jeng WY, Chen CK, Zhang Y, Song Y, Kuo CJ, Yin F, Oldfield E, Wang AH: Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10022-7. Epub 2007 May 29. |
| Groups | Approved |
| Direct Classification | Bisphosphonates |
| SMILES | NCCCC(O)(P(O)(O)=O)P(O)(O)=O |
| Pathways | Alendronate Action Pathway |
| PharmGKB | PA448082 |
| ChEMBL | CHEMBL870 |
