| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10028823 | HBV | ENSG00000138413.14 | protein_coding | IDH1 | Yes | No | 3417 | O75874 |
| TVIS10024841 | HBV | ENSG00000138413.14 | protein_coding | IDH1 | Yes | No | 3417 | O75874 |
| TVIS30003227 | HIV | ENSG00000138413.14 | protein_coding | IDH1 | Yes | No | 3417 | O75874 |
| TVIS30052261 | HIV | ENSG00000138413.14 | protein_coding | IDH1 | Yes | No | 3417 | O75874 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | IDH1 |
|---|---|
| DrugBank ID | DB14568 |
| Drug Name | Ivosidenib |
| Target ID | BE0001251 |
| UniProt ID | O75874 |
| Regulation Type | inhibitor |
| PubMed IDs | 31413655; 33457062 |
| Citations | Megias-Vericat JE, Ballesta-Lopez O, Barragan E, Montesinos P: IDH1-mutated relapsed or refractory AML: current challenges and future prospects. Blood Lymphat Cancer. 2019 Jun 27;9:19-32. doi: 10.2147/BLCTT.S177913. eCollection 2019.@@Merchant SL, Culos K, Wyatt H: Ivosidenib: IDH1 Inhibitor for the Treatment of Acute Myeloid Leukemia. J Adv Pract Oncol. 2019 Jul;10(5):494-500. doi: 10.6004/jadpro.2019.10.5.7. Epub 2019 Jul 1. |
| Groups | Approved; Investigational |
| Direct Classification | Proline and derivatives |
| SMILES | [H][C@@](N(C(=O)[C@]1([H])CCC(=O)N1C1=NC=CC(=C1)C#N)C1=CC(F)=CN=C1)(C(=O)NC1CC(F)(F)C1)C1=C(Cl)C=CC=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL3989958 |
