| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10028823 | HBV | ENSG00000138413.14 | protein_coding | IDH1 | Yes | No | 3417 | O75874 |
| TVIS10024841 | HBV | ENSG00000138413.14 | protein_coding | IDH1 | Yes | No | 3417 | O75874 |
| TVIS30003227 | HIV | ENSG00000138413.14 | protein_coding | IDH1 | Yes | No | 3417 | O75874 |
| TVIS30052261 | HIV | ENSG00000138413.14 | protein_coding | IDH1 | Yes | No | 3417 | O75874 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | IDH1 |
|---|---|
| DrugBank ID | DB16267 |
| Drug Name | Olutasidenib |
| Target ID | BE0001251 |
| UniProt ID | O75874 |
| Regulation Type | inhibitor |
| PubMed IDs | 31971798 |
| Citations | Caravella JA, Lin J, Diebold RB, Campbell AM, Ericsson A, Gustafson G, Wang Z, Castro J, Clarke A, Gotur D, Josephine HR, Katz M, Kershaw M, Yao L, Toms AV, Barr KJ, Dinsmore CJ, Walker D, Ashwell S, Lu W: Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor. J Med Chem. 2020 Feb 27;63(4):1612-1623. doi: 10.1021/acs.jmedchem.9b01423. Epub 2020 Feb 12.@@de la Fuente MI, Colman H, Rosenthal M, Van Tine BA, Levacic D, Walbert T, Gan HK, Vieito M, Milhem MM, Lipford K, Forsyth S, Guichard SM, Mikhailov Y, Sedkov A, Brevard J, Kelly PF, Mohamed H, Monga V: Olutasidenib (FT-2102) in patients with relapsed or refractory IDH1-mutant glioma: a multicenter, open-label, phase 1b/2 trial Neuro-oncology. |
| Groups | Approved; Investigational |
| Direct Classification | |
| SMILES | C[C@H](NC1=CC=C(C#N)N(C)C1=O)C1=CC2=C(NC1=O)C=CC(Cl)=C2 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL4297610 |
