| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10015984 | HBV | ENSG00000178035.13 | protein_coding | IMPDH2 | No | No | 3615 | P12268 |
| TVIS10029281 | HBV | ENSG00000178035.13 | protein_coding | IMPDH2 | No | No | 3615 | P12268 |
| TVIS10047149 | HBV | ENSG00000178035.13 | protein_coding | IMPDH2 | No | No | 3615 | P12268 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | IMPDH2 |
|---|---|
| DrugBank ID | DB00811 |
| Drug Name | Ribavirin |
| Target ID | BE0000722 |
| UniProt ID | P12268 |
| Regulation Type | |
| PubMed IDs | 10722482; 29792360 |
| Citations | Markland W, McQuaid TJ, Jain J, Kwong AD: Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon. Antimicrob Agents Chemother. 2000 Apr;44(4):859-66.@@Shah CP, Kharkar PS: Newer human inosine 5'-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents. J Enzyme Inhib Med Chem. 2018 Dec;33(1):972-977. doi: 10.1080/14756366.2018.1474211. |
| Groups | Approved |
| Direct Classification | Triazole ribonucleosides and ribonucleotides |
| SMILES | NC(=O)C1=NN(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |
| Pathways | |
| PharmGKB | PA451241 |
| ChEMBL | CHEMBL1643 |
