| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10015984 | HBV | ENSG00000178035.13 | protein_coding | IMPDH2 | No | No | 3615 | P12268 |
| TVIS10029281 | HBV | ENSG00000178035.13 | protein_coding | IMPDH2 | No | No | 3615 | P12268 |
| TVIS10047149 | HBV | ENSG00000178035.13 | protein_coding | IMPDH2 | No | No | 3615 | P12268 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | IMPDH2 |
|---|---|
| DrugBank ID | DB01024 |
| Drug Name | Mycophenolic acid |
| Target ID | BE0000722 |
| UniProt ID | P12268 |
| Regulation Type | inhibitor |
| PubMed IDs | 15621150; 17496727; 15614187; 16647299; 16629948 |
| Citations | Vannozzi F, Filipponi F, Di Paolo A, Danesi R, Urbani L, Bocci G, Catalano G, De Simone P, Mosca F, Del Tacca M: An exploratory study on pharmacogenetics of inosine-monophosphate dehydrogenase II in peripheral mononuclear cells from liver-transplant recipients. Transplant Proc. 2004 Nov;36(9):2787-90.@@Wang J, Zeevi A, Webber S, Girnita DM, Addonizio L, Selby R, Hutchinson IV, Burckart GJ: A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity. Pharmacogenet Genomics. 2007 Apr;17(4):283-90.@@Penuelas S, Noe V, Morales R, Ciudad CJ: Sensitization of human erythroleukemia K562 cells resistant to methotrexate by inhibiting IMPDH. Med Sci Monit. 2005 Jan;11(1):BR6-12.@@Yam P, Jensen M, Akkina R, Anderson J, Villacres MC, Wu J, Zaia JA, Yee JK: Ex vivo selection and expansion of cells based on expression of a mutated inosine monophosphate dehydrogenase 2 after HIV vector transduction: effects on lymphocytes, monocytes, and CD34+ stem cells. Mol Ther. 2006 Aug;14(2):236-44. Epub 2006 May 2.@@Dzidic A, Prgomet C, Mohr A, Meyer K, Bauer J, Meyer HH, Pfaffl MW: Effects of mycophenolic acid on inosine monophosphate dehydrogenase I and II mRNA expression in white blood cells and various tissues in sheep. J Vet Med A Physiol Pathol Clin Med. 2006 May;53(4):163-9. |
| Groups | Approved; Investigational |
| Direct Classification | Phthalides |
| SMILES | COC1=C(CC=C(/C)CCC(O)=O)C(O)=C2C(=O)OCC2=C1C |
| Pathways | Mycophenolic Acid Metabolism Pathway |
| PharmGKB | PA164748728 |
| ChEMBL | CHEMBL866 |
