| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30038735 | HIV | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS20018682 | HPV | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS20034843 | HPV | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS44012427 | HTLV-1 | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS44023718 | HTLV-1 | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS44051116 | HTLV-1 | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MAP2K1 |
|---|---|
| DrugBank ID | DB05239 |
| Drug Name | Cobimetinib |
| Target ID | BE0000870 |
| UniProt ID | Q02750 |
| Regulation Type | inhibitor |
| PubMed IDs | 26384788 |
| Citations | Singh A, Ruan Y, Tippett T, Narendran A: Targeted inhibition of MEK1 by cobimetinib leads to differentiation and apoptosis in neuroblastoma cells. J Exp Clin Cancer Res. 2015 Sep 18;34:104. doi: 10.1186/s13046-015-0222-x. |
| Groups | Approved; Investigational |
| Direct Classification | Anthranilamides |
| SMILES | OC1(CN(C1)C(=O)C1=C(NC2=C(F)C=C(I)C=C2)C(F)=C(F)C=C1)[C@@H]1CCCCN1 |
| Pathways | |
| PharmGKB | PA166160044 |
| ChEMBL | CHEMBL2146883 |
