| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30038735 | HIV | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS20018682 | HPV | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS20034843 | HPV | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS44012427 | HTLV-1 | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS44023718 | HTLV-1 | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS44051116 | HTLV-1 | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MAP2K1 |
|---|---|
| DrugBank ID | DB06616 |
| Drug Name | Bosutinib |
| Target ID | BE0000870 |
| UniProt ID | Q02750 |
| Regulation Type | inhibitor |
| PubMed IDs | 19039322 |
| Citations | Remsing Rix LL, Rix U, Colinge J, Hantschel O, Bennett KL, Stranzl T, Muller A, Baumgartner C, Valent P, Augustin M, Till JH, Superti-Furga G: Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells. Leukemia. 2009 Mar;23(3):477-85. doi: 10.1038/leu.2008.334. Epub 2008 Nov 27. |
| Groups | Approved |
| Direct Classification | 4-aminoquinolines |
| SMILES | COC1=CC(NC2=C(C=NC3=CC(OCCCN4CCN(C)CC4)=C(OC)C=C23)C#N)=C(Cl)C=C1Cl |
| Pathways | Bosutinib Inhibition of BCR-ABL |
| PharmGKB | |
| ChEMBL | CHEMBL288441 |
