| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30014934 | HIV | ENSG00000172819.17 | protein_coding | RARG | No | No | 5916 | A8K3H3 P13631 |
| TVIS20027439 | HPV | ENSG00000172819.17 | protein_coding | RARG | No | No | 5916 | A8K3H3 P13631 |
| TVIS20020554 | HPV | ENSG00000172819.17 | protein_coding | RARG | No | No | 5916 | A8K3H3 P13631 |
| TVIS44023408 | HTLV-1 | ENSG00000172819.17 | protein_coding | RARG | No | No | 5916 | A8K3H3 P13631 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | RARG |
|---|---|
| DrugBank ID | DB00523 |
| Drug Name | Alitretinoin |
| Target ID | BE0000144 |
| UniProt ID | P13631 |
| Regulation Type | agonist |
| PubMed IDs | 17277115; 16788091; 16880407; 19678713; 10592235 |
| Citations | Dzhagalov I, Chambon P, He YW: Regulation of CD8+ T lymphocyte effector function and macrophage inflammatory cytokine production by retinoic acid receptor gamma. J Immunol. 2007 Feb 15;178(4):2113-21.@@Parrella E, Gianni M, Fratelli M, Barzago MM, Raska I Jr, Diomede L, Kurosaki M, Pisano C, Carminati P, Merlini L, Dallavalle S, Tavecchio M, Rochette-Egly C, Terao M, Garattini E: Antitumor activity of the retinoid-related molecules (E)-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: Role of retinoic acid receptor gamma and retinoid-independent pathways. Mol Pharmacol. 2006 Sep;70(3):909-24. Epub 2006 Jun 20.@@Li M, Hener P, Zhang Z, Kato S, Metzger D, Chambon P: Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11736-41. Epub 2006 Jul 31.@@Garnock-Jones KP, Perry CM: Alitretinoin: in severe chronic hand eczema. Drugs. 2009 Aug 20;69(12):1625-34. doi: 10.2165/11202200-000000000-00000.@@Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. |
| Groups | Approved; Investigational |
| Direct Classification | Retinoids |
| SMILES | CC(C=CC1=C(C)CCCC1(C)C)=CC=CC(C)=CC(O)=O |
| Pathways | Retinol Metabolism; Vitamin A Deficiency |
| PharmGKB | PA164746900 |
| ChEMBL | CHEMBL705 |
