| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30014934 | HIV | ENSG00000172819.17 | protein_coding | RARG | No | No | 5916 | A8K3H3 P13631 |
| TVIS20027439 | HPV | ENSG00000172819.17 | protein_coding | RARG | No | No | 5916 | A8K3H3 P13631 |
| TVIS20020554 | HPV | ENSG00000172819.17 | protein_coding | RARG | No | No | 5916 | A8K3H3 P13631 |
| TVIS44023408 | HTLV-1 | ENSG00000172819.17 | protein_coding | RARG | No | No | 5916 | A8K3H3 P13631 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | RARG |
|---|---|
| DrugBank ID | DB00755 |
| Drug Name | Tretinoin |
| Target ID | BE0000144 |
| UniProt ID | P13631 |
| Regulation Type | agonist |
| PubMed IDs | 17139284; 17016423; 1332684; 8394693; 10792999; 10592235; 11752352; 9160172 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Reddy AP, Chen JY, Zacharewski T, Gronemeyer H, Voorhees JJ, Fisher GJ: Characterization and purification of human retinoic acid receptor-gamma 1 overexpressed in the baculovirus-insect cell system. Biochem J. 1992 Nov 1;287 ( Pt 3):833-40.@@Kamei Y, Kawada T, Kazuki R, Sugimoto E: Retinoic acid receptor gamma 2 gene expression is up-regulated by retinoic acid in 3T3-L1 preadipocytes. Biochem J. 1993 Aug 1;293 ( Pt 3):807-12.@@Borger DR, Mi Y, Geslani G, Zyzak LL, Batova A, Engin TS, Pirisi L, Creek KE: Retinoic acid resistance at late stages of human papillomavirus type 16-mediated transformation of human keratinocytes arises despite intact retinoid signaling and is due to a loss of sensitivity to transforming growth factor-beta. Virology. 2000 May 10;270(2):397-407.@@Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Regazzi MB, Iacona I, Gervasutti C, Lazzarino M, Toma S: Clinical pharmacokinetics of tretinoin. Clin Pharmacokinet. 1997 May;32(5):382-402. doi: 10.2165/00003088-199732050-00004. |
| Groups | Approved; Investigational; Nutraceutical |
| Direct Classification | |
| SMILES | CC(C=CC1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |
| Pathways | Retinol Metabolism; Vitamin A Deficiency |
| PharmGKB | PA164746900 |
| ChEMBL | CHEMBL38 |
