| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10045810 | HBV | ENSG00000111424.12 | protein_coding | VDR | No | No | 7421 | P11473 |
| TVIS30006137 | HIV | ENSG00000111424.12 | protein_coding | VDR | No | No | 7421 | P11473 |
| TVIS30019074 | HIV | ENSG00000111424.12 | protein_coding | VDR | No | No | 7421 | P11473 |
| TVIS30077286 | HIV | ENSG00000111424.12 | protein_coding | VDR | No | No | 7421 | P11473 |
| TVIS30079341 | HIV | ENSG00000111424.12 | protein_coding | VDR | No | No | 7421 | P11473 |
| TVIS20045047 | HPV | ENSG00000111424.12 | protein_coding | VDR | No | No | 7421 | P11473 |
| TVIS44017496 | HTLV-1 | ENSG00000111424.12 | protein_coding | VDR | No | No | 7421 | P11473 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | VDR |
|---|---|
| DrugBank ID | DB00153 |
| Drug Name | Ergocalciferol |
| Target ID | BE0000779 |
| UniProt ID | P11473 |
| Regulation Type | agonist |
| PubMed IDs | 17218095; 16949927; 17519354; 20525913; 20091647; 18290715; 17440943; 17207992; 11752352 |
| Citations | Carvallo L, Henriquez B, Olate J, van Wijnen AJ, Lian JB, Stein GS, Onate S, Stein JL, Montecino M: The 1alpha,25-dihydroxy Vitamin D3 receptor preferentially recruits the coactivator SRC-1 during up-regulation of the osteocalcin gene. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):420-4. Epub 2007 Jan 10.@@Liu W, Tretiakova M, Kong J, Turkyilmaz M, Li YC, Krausz T: Expression of vitamin D3 receptor in kidney tumors. Hum Pathol. 2006 Oct;37(10):1268-78. Epub 2006 Jul 27.@@Ewing AK, Attner M, Chakravarti D: Novel regulatory role for human Acf1 in transcriptional repression of vitamin D3 receptor-regulated genes. Mol Endocrinol. 2007 Aug;21(8):1791-806. Epub 2007 May 22.@@Gallagher JC, Sai AJ: Vitamin D insufficiency, deficiency, and bone health. J Clin Endocrinol Metab. 2010 Jun;95(6):2630-3. doi: 10.1210/jc.2010-0918.@@Straube S, Derry S, Moore RA, McQuay HJ: Vitamin D for the treatment of chronic painful conditions in adults. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD007771. doi: 10.1002/14651858.CD007771.pub2.@@Jurutka PW, Bartik L, Whitfield GK, Mathern DR, Barthel TK, Gurevich M, Hsieh JC, Kaczmarska M, Haussler CA, Haussler MR: Vitamin D receptor: key roles in bone mineral pathophysiology, molecular mechanism of action, and novel nutritional ligands. J Bone Miner Res. 2007 Dec;22 Suppl 2:V2-10. doi: 10.1359/jbmr.07s216.@@Mikhak B, Hunter DJ, Spiegelman D, Platz EA, Hollis BW, Giovannucci E: Vitamin D receptor (VDR) gene polymorphisms and haplotypes, interactions with plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, and prostate cancer risk. Prostate. 2007 Jun 15;67(9):911-23.@@Marks HD, Fleet JC, Peleg S: Transgenic expression of the human Vitamin D receptor (hVDR) in the duodenum of VDR-null mice attenuates the age-dependent decline in calcium absorption. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):513-6. Epub 2007 Jan 5.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Nutraceutical |
| Direct Classification | Vitamin D and derivatives |
| SMILES | CC(C)[C@@H](C)C=C[C@@H](C)[C@@]1([H])CC[C@@]2([H])C(CCC[C@]12C)=CC=C1C[C@@H](O)CCC1=C |
| Pathways | |
| PharmGKB | PA449484 |
| ChEMBL | CHEMBL1536 |
