| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30043802 | HIV | ENSG00000131747.15 | protein_coding | TOP2A | Yes | No | 7153 | P11388 |
| TVIS44051346 | HTLV-1 | ENSG00000131747.15 | protein_coding | TOP2A | Yes | No | 7153 | P11388 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TOP2A |
|---|---|
| DrugBank ID | DB06013 |
| Drug Name | Aldoxorubicin |
| Target ID | BE0000742 |
| UniProt ID | P11388 |
| Regulation Type | inhibitor |
| PubMed IDs | 25312684 |
| Citations | Chawla SP, Chua VS, Hendifar AF, Quon DV, Soman N, Sankhala KK, Wieland DS, Levitt DJ: A phase 1B/2 study of aldoxorubicin in patients with soft tissue sarcoma. Cancer. 2015 Feb 15;121(4):570-9. doi: 10.1002/cncr.29081. Epub 2014 Oct 13. |
| Groups | Investigational |
| Direct Classification | Anthracyclines |
| SMILES | COC1=C2C(=O)C3=C(O)C4=C(C[C@](O)(C[C@@H]4O[C@H]4C[C@H](N)[C@H](O)[C@H](C)O4)C(CO)=NNC(=O)CCCCCN4C(=O)C=CC4=O)C(O)=C3C(=O)C2=CC=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL2107818 |
