| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10006400 | HBV | ENSG00000006071.16 | protein_coding | ABCC8 | No | No | 6833 | Q09428 |
| TVIS10014476 | HBV | ENSG00000006071.16 | protein_coding | ABCC8 | No | No | 6833 | Q09428 |
| TVIS20010586 | HPV | ENSG00000006071.16 | protein_coding | ABCC8 | No | No | 6833 | Q09428 |
| TVIS44004571 | HTLV-1 | ENSG00000006071.16 | protein_coding | ABCC8 | No | No | 6833 | Q09428 |
| TVIS44020396 | HTLV-1 | ENSG00000006071.16 | protein_coding | ABCC8 | No | No | 6833 | Q09428 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ABCC8 |
|---|---|
| DrugBank ID | DB00731 |
| Drug Name | Nateglinide |
| Target ID | BE0000207 |
| UniProt ID | Q09428 |
| Regulation Type | inhibitor |
| PubMed IDs | 10773014; 11716850; 12196472; 12604678; 12764427; 11728565 |
| Citations | Hu S, Wang S, Fanelli B, Bell PA, Dunning BE, Geisse S, Schmitz R, Boettcher BR: Pancreatic beta-cell K(ATP) channel activity and membrane-binding studies with nateglinide: A comparison with sulfonylureas and repaglinide. J Pharmacol Exp Ther. 2000 May;293(2):444-52.@@Sunaga Y, Gonoi T, Shibasaki T, Ichikawa K, Kusama H, Yano H, Seino S: The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide. Eur J Pharmacol. 2001 Nov 9;431(1):119-25.@@Hansen AM, Christensen IT, Hansen JB, Carr RD, Ashcroft FM, Wahl P: Differential interactions of nateglinide and repaglinide on the human beta-cell sulphonylurea receptor 1. Diabetes. 2002 Sep;51(9):2789-95.@@Chachin M, Yamada M, Fujita A, Matsuoka T, Matsushita K, Kurachi Y: Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea or benzamido moiety, specifically inhibits pancreatic beta-cell-type K(ATP) channels. J Pharmacol Exp Ther. 2003 Mar;304(3):1025-32.@@Norman P, Rabasseda X: Nateglinide: A structurally novel, short-acting, hypoglycemic agent. Drugs Today (Barc). 2001 Jun;37(6):411-426.@@Dornhorst A: Insulinotropic meglitinide analogues. Lancet. 2001 Nov 17;358(9294):1709-16. |
| Groups | Approved; Investigational |
| Direct Classification | Phenylalanine and derivatives |
| SMILES | CC(C)[C@H]1CC[C@@H](CC1)C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O |
| Pathways | Nateglinide Action Pathway |
| PharmGKB | PA450600 |
| ChEMBL | CHEMBL783 |
