| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10006400 | HBV | ENSG00000006071.16 | protein_coding | ABCC8 | No | No | 6833 | Q09428 |
| TVIS10014476 | HBV | ENSG00000006071.16 | protein_coding | ABCC8 | No | No | 6833 | Q09428 |
| TVIS20010586 | HPV | ENSG00000006071.16 | protein_coding | ABCC8 | No | No | 6833 | Q09428 |
| TVIS44004571 | HTLV-1 | ENSG00000006071.16 | protein_coding | ABCC8 | No | No | 6833 | Q09428 |
| TVIS44020396 | HTLV-1 | ENSG00000006071.16 | protein_coding | ABCC8 | No | No | 6833 | Q09428 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ABCC8 |
|---|---|
| DrugBank ID | DB01120 |
| Drug Name | Gliclazide |
| Target ID | BE0000207 |
| UniProt ID | Q09428 |
| Regulation Type | binder |
| PubMed IDs | 11078468; 11078469; 11484080; 11574406; 12475777 |
| Citations | Gribble FM, Ashcroft FM: Sulfonylurea sensitivity of adenosine triphosphate-sensitive potassium channels from beta cells and extrapancreatic tissues. Metabolism. 2000 Oct;49(10 Suppl 2):3-6.@@Harrower A: Gliclazide modified release: from once-daily administration to 24-hour blood glucose control. Metabolism. 2000 Oct;49(10 Suppl 2):7-11.@@Lawrence CL, Proks P, Rodrigo GC, Jones P, Hayabuchi Y, Standen NB, Ashcroft FM: Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells. Diabetologia. 2001 Aug;44(8):1019-25.@@Reimann F, Ashcroft FM, Gribble FM: Structural basis for the interference between nicorandil and sulfonylurea action. Diabetes. 2001 Oct;50(10):2253-9.@@Proks P, Reimann F, Green N, Gribble F, Ashcroft F: Sulfonylurea stimulation of insulin secretion. Diabetes. 2002 Dec;51 Suppl 3:S368-76. |
| Groups | Approved |
| Direct Classification | |
| SMILES | [H][C@@]12CCC[C@]1([H])CN(C2)NC(=O)NS(=O)(=O)C1=CC=C(C)C=C1 |
| Pathways | Gliclazide Action Pathway |
| PharmGKB | PA10892 |
| ChEMBL | CHEMBL427216 |
