| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10036449 | HBV | ENSG00000196639.7 | protein_coding | HRH1 | No | No | 3269 | P35367 |
| TVIS10050122 | HBV | ENSG00000196639.7 | protein_coding | HRH1 | No | No | 3269 | P35367 |
| TVIS30085065 | HIV | ENSG00000196639.7 | protein_coding | HRH1 | No | No | 3269 | P35367 |
| TVIS20007380 | HPV | ENSG00000196639.7 | protein_coding | HRH1 | No | No | 3269 | P35367 |
| TVIS20007381 | HPV | ENSG00000196639.7 | protein_coding | HRH1 | No | No | 3269 | P35367 |
| TVIS20010779 | HPV | ENSG00000196639.7 | protein_coding | HRH1 | No | No | 3269 | P35367 |
| TVIS20035928 | HPV | ENSG00000196639.7 | protein_coding | HRH1 | No | No | 3269 | P35367 |
| TVIS20057329 | HPV | ENSG00000196639.7 | protein_coding | HRH1 | No | No | 3269 | P35367 |
| TVIS20021555 | HPV | ENSG00000196639.7 | protein_coding | HRH1 | No | No | 3269 | P35367 |
| TVIS20056904 | HPV | ENSG00000196639.7 | protein_coding | HRH1 | No | No | 3269 | P35367 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | HRH1 |
|---|---|
| DrugBank ID | DB00920 |
| Drug Name | Ketotifen |
| Target ID | BE0000442 |
| UniProt ID | P35367 |
| Regulation Type | antagonist |
| PubMed IDs | 7893266; 1434122; 16404130; 8836617; 8101246; 18490184 |
| Citations | Mita H, Shida T: Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes. Arzneimittelforschung. 1995 Jan;45(1):36-40.@@Okabe S, Nakaji S, Tachibana M: Effect of ketotifen on acute gastric lesions and gastric secretion in rats. Jpn J Pharmacol. 1992 Jun;59(2):251-4.@@Hashimoto T, Ohata H, Honda K: Lysophosphatidic acid (LPA) induces plasma exudation and histamine release in mice via LPA receptors. J Pharmacol Sci. 2006 Jan;100(1):82-7. Epub 2006 Jan 11.@@Ito K, Sakamoto T, Hayashi Y, Morishita M, Shibata E, Sakai K, Takeuchi Y, Torii S: Role of tachykinin and bradykinin receptors and mast cells in gaseous formaldehyde-induced airway microvascular leakage in rats. Eur J Pharmacol. 1996 Jul 4;307(3):291-8.@@Yokoyama H, Iinuma K, Yanai K, Watanabe T, Sakurai E, Onodera K: Proconvulsant effect of ketotifen, a histamine H1 antagonist, confirmed by the use of d-chlorpheniramine with monitoring electroencephalography. Methods Find Exp Clin Pharmacol. 1993 Apr;15(3):183-8.@@Werner-Klein M, Goggel R, Westhof A, Erb KJ: Development and characterisation of a novel and rapid lung eosinophil influx model in the rat. Pulm Pharmacol Ther. 2008 Aug;21(4):648-56. doi: 10.1016/j.pupt.2008.03.002. Epub 2008 Apr 7. |
| Groups | Approved |
| Direct Classification | Cycloheptathiophenes |
| SMILES | CN1CCC(CC1)=C1C2=C(SC=C2)C(=O)CC2=CC=CC=C12 |
| Pathways | Ketotifen H1-Antihistamine Action |
| PharmGKB | PA450152 |
| ChEMBL | CHEMBL534 |
