| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10017835 | HBV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
| TVIS10049964 | HBV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
| TVIS30004190 | HIV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
| TVIS30079024 | HIV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
| TVIS30075830 | HIV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
| TVIS30082812 | HIV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
| TVIS30020969 | HIV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
| TVIS20007944 | HPV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
| TVIS20063531 | HPV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
| TVIS20018278 | HPV | ENSG00000136928.7 | protein_coding | GABBR2 | No | No | 9568 | H9NIL8 O75899 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | GABBR2 |
|---|---|
| DrugBank ID | DB08891 |
| Drug Name | Arbaclofen |
| Target ID | BE0002340 |
| UniProt ID | O75899 |
| Regulation Type | agonist |
| PubMed IDs | 10658574; 15235087; 8388192; 10751439; 11008066; 19303900; 10328880; 10545129 |
| Citations | Belley M, Sullivan R, Reeves A, Evans J, O'Neill G, Ng GY: Synthesis of the nanomolar photoaffinity GABA(B) receptor ligand CGP 71872 reveals diversity in the tissue distribution of GABA(B) receptor forms. Bioorg Med Chem. 1999 Dec;7(12):2697-704.@@Braun M, Wendt A, Buschard K, Salehi A, Sewing S, Gromada J, Rorsman P: GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin. J Physiol. 2004 Sep 1;559(Pt 2):397-409. Epub 2004 Jul 2.@@Bowery NG: GABAB receptor pharmacology. Annu Rev Pharmacol Toxicol. 1993;33:109-47.@@Filippov AK, Couve A, Pangalos MN, Walsh FS, Brown DA, Moss SJ: Heteromeric assembly of GABA(B)R1 and GABA(B)R2 receptor subunits inhibits Ca(2+) current in sympathetic neurons. J Neurosci. 2000 Apr 15;20(8):2867-74.@@Jones KA, Tamm JA, Craig DA, Ph D, Yao W, Panico R: Signal transduction by GABA(B) receptor heterodimers. Neuropsychopharmacology. 2000 Oct;23(4 Suppl):S41-9.@@Lehmann A: GABAB receptors as drug targets to treat gastroesophageal reflux disease. Pharmacol Ther. 2009 Jun;122(3):239-45. doi: 10.1016/j.pharmthera.2009.02.008. Epub 2009 Mar 19.@@Martin SC, Russek SJ, Farb DH: Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1. Mol Cell Neurosci. 1999 Mar;13(3):180-91.@@Pittman QJ: The action is at the terminal. J Physiol. 1999 Nov 1;520 Pt 3:629. |
| Groups | Investigational |
| Direct Classification | Gamma amino acids and derivatives |
| SMILES | [H][C@@](CN)(CC(O)=O)C1=CC=C(Cl)C=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL301742 |
