| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30078583 | HIV | ENSG00000113749.8 | protein_coding | HRH2 | No | No | 3274 | A0A1B0GTK7 P25021 |
| TVIS20009148 | HPV | ENSG00000113749.8 | protein_coding | HRH2 | No | No | 3274 | A0A1B0GTK7 P25021 |
| TVIS20009386 | HPV | ENSG00000113749.8 | protein_coding | HRH2 | No | No | 3274 | A0A1B0GTK7 P25021 |
| TVIS20059821 | HPV | ENSG00000113749.8 | protein_coding | HRH2 | No | No | 3274 | A0A1B0GTK7 P25021 |
| TVIS44038999 | HTLV-1 | ENSG00000113749.8 | protein_coding | HRH2 | No | No | 3274 | A0A1B0GTK7 P25021 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | HRH2 |
|---|---|
| DrugBank ID | DB00501 |
| Drug Name | Cimetidine |
| Target ID | BE0000112 |
| UniProt ID | P25021 |
| Regulation Type | antagonist |
| PubMed IDs | 11752352; 10950107; 8863950; 16723495; 31334975; 12477078; 14528656; 6085389 |
| Citations | Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Hernandez-Munoz R, Montiel-Ruiz C, Vazquez-Martinez O: Gastric mucosal cell proliferation in ethanol-induced chronic mucosal injury is related to oxidative stress and lipid peroxidation in rats. Lab Invest. 2000 Aug;80(8):1161-9.@@Kuint J, Linder N, Reichman B: Hypoxemia associated with cimetidine therapy in a newborn infant. Am J Perinatol. 1996 Jul;13(5):301-3.@@Takahashi HK, Watanabe T, Yokoyama A, Iwagaki H, Yoshino T, Tanaka N, Nishibori M: Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol. 2006 Aug;70(2):450-3. Epub 2006 May 24.@@Pino MA, Azer SA: Cimetidine .@@Duda D, Lorenz W, Celik I: Histamine release in mesenteric traction syndrome during abdominal aortic aneurysm surgery: prophylaxis with H1 and H2 antihistamines. Inflamm Res. 2002 Oct;51(10):495-9. doi: 10.1007/pl00012418.@@Duda D, Lorenz W, Celik I: [Mesenteric traction syndrome during the operation of aneurysms of the abdominal aorta--histamine release and prophylaxis with antihistaminics]. Anaesthesiol Reanim. 2003;28(4):97-103.@@Kirch W, Hutt HJ, Heidemann H, Ramsch K, Janisch HD, Ohnhaus EE: Drug interactions with nitrendipine. J Cardiovasc Pharmacol. 1984;6 Suppl 7:S982-5. |
| Groups | Approved; Investigational |
| Direct Classification | Imidazoles |
| SMILES | CNC(NCCSCC1=C(C)NC=N1)=NC#N |
| Pathways | Cimetidine Metabolism Pathway; Cimetidine Action Pathway |
| PharmGKB | PA449001 |
| ChEMBL | CHEMBL30 |
