| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20061995 | HPV | ENSG00000106546.14 | protein_coding | AHR | No | No | 196 | P35869 |
| TVIS20031176 | HPV | ENSG00000106546.14 | protein_coding | AHR | No | No | 196 | P35869 |
| TVIS20065987 | HPV | ENSG00000106546.14 | protein_coding | AHR | No | No | 196 | P35869 |
| TVIS20061884 | HPV | ENSG00000106546.14 | protein_coding | AHR | No | No | 196 | P35869 |
| TVIS20061827 | HPV | ENSG00000106546.14 | protein_coding | AHR | No | No | 196 | P35869 |
| TVIS20062072 | HPV | ENSG00000106546.14 | protein_coding | AHR | No | No | 196 | P35869 |
| TVIS20038159 | HPV | ENSG00000106546.14 | protein_coding | AHR | No | No | 196 | P35869 |
| TVIS20068307 | HPV | ENSG00000106546.14 | protein_coding | AHR | No | No | 196 | P35869 |
| TVIS20061404 | HPV | ENSG00000106546.14 | protein_coding | AHR | No | No | 196 | P35869 |
| TVIS20016969 | HPV | ENSG00000106546.14 | protein_coding | AHR | No | No | 196 | P35869 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | AHR |
|---|---|
| DrugBank ID | DB01097 |
| Drug Name | Leflunomide |
| Target ID | BE0003721 |
| UniProt ID | P35869 |
| Regulation Type | agonist |
| PubMed IDs | 20957046; 17327465 |
| Citations | O'Donnell EF, Saili KS, Koch DC, Kopparapu PR, Farrer D, Bisson WH, Mathew LK, Sengupta S, Kerkvliet NI, Tanguay RL, Kolluri SK: The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor. PLoS One. 2010 Oct 1;5(10). pii: e13128. doi: 10.1371/journal.pone.0013128.@@Hu W, Sorrentino C, Denison MS, Kolaja K, Fielden MR: Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro. Mol Pharmacol. 2007 Jun;71(6):1475-86. Epub 2007 Feb 27. |
| Groups | Approved; Investigational |
| Direct Classification | Aromatic anilides |
| SMILES | CC1=C(C=NO1)C(=O)NC1=CC=C(C=C1)C(F)(F)F |
| Pathways | |
| PharmGKB | PA450192 |
| ChEMBL | CHEMBL960 |
